The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells

Second- and third-generation inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase activity (EGFR-TKIs) are improving the treatment of patients with non-small cell lung cancer. Here we established two sublines (BR1-8 and BR2-3) resistant to a second-generation inhibitor, afatinib, fr...

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Detalles Bibliográficos
Autores principales: Murakami, Yuichi, Sonoda, Kahori, Abe, Hideyuki, Watari, Kosuke, Kusakabe, Daiki, Azuma, Koichi, Kawahara, Akihiko, Akiba, Jun, Oneyama, Chitose, Pachter, Jonathan A., Sakai, Kazuko, Nishio, Kazuto, Kuwano, Michihiko, Ono, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642590/
https://www.ncbi.nlm.nih.gov/pubmed/29050315
http://dx.doi.org/10.18632/oncotarget.19982

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