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State-of-the-art considerations in small cell lung cancer brain metastases
BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of pre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642633/ https://www.ncbi.nlm.nih.gov/pubmed/29050358 http://dx.doi.org/10.18632/oncotarget.19333 |
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author | Lukas, Rimas V. Gondi, Vinai Kamson, David O. Kumthekar, Priya Salgia, Ravi |
author_facet | Lukas, Rimas V. Gondi, Vinai Kamson, David O. Kumthekar, Priya Salgia, Ravi |
author_sort | Lukas, Rimas V. |
collection | PubMed |
description | BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments. DESIGN: A comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed. RESULTS: SCLC brain metastases continue to have a poor prognosis. Both unique aspects of SCLC brain metastases as well as features seen more universally across other solid tumor brain metastases are discussed. Systemic therapeutic studies and radiotherapeutic approaches are reviewed. CONCLUSIONS: A clearer understanding of SCLC brain metastases will help lay the framework for studies which will hopefully translate into meaningful therapeutic options for these patients. |
format | Online Article Text |
id | pubmed-5642633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56426332017-10-18 State-of-the-art considerations in small cell lung cancer brain metastases Lukas, Rimas V. Gondi, Vinai Kamson, David O. Kumthekar, Priya Salgia, Ravi Oncotarget Review BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments. DESIGN: A comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed. RESULTS: SCLC brain metastases continue to have a poor prognosis. Both unique aspects of SCLC brain metastases as well as features seen more universally across other solid tumor brain metastases are discussed. Systemic therapeutic studies and radiotherapeutic approaches are reviewed. CONCLUSIONS: A clearer understanding of SCLC brain metastases will help lay the framework for studies which will hopefully translate into meaningful therapeutic options for these patients. Impact Journals LLC 2017-07-18 /pmc/articles/PMC5642633/ /pubmed/29050358 http://dx.doi.org/10.18632/oncotarget.19333 Text en Copyright: © 2017 Lukas et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Lukas, Rimas V. Gondi, Vinai Kamson, David O. Kumthekar, Priya Salgia, Ravi State-of-the-art considerations in small cell lung cancer brain metastases |
title | State-of-the-art considerations in small cell lung cancer brain metastases |
title_full | State-of-the-art considerations in small cell lung cancer brain metastases |
title_fullStr | State-of-the-art considerations in small cell lung cancer brain metastases |
title_full_unstemmed | State-of-the-art considerations in small cell lung cancer brain metastases |
title_short | State-of-the-art considerations in small cell lung cancer brain metastases |
title_sort | state-of-the-art considerations in small cell lung cancer brain metastases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642633/ https://www.ncbi.nlm.nih.gov/pubmed/29050358 http://dx.doi.org/10.18632/oncotarget.19333 |
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