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State-of-the-art considerations in small cell lung cancer brain metastases

BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of pre...

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Autores principales: Lukas, Rimas V., Gondi, Vinai, Kamson, David O., Kumthekar, Priya, Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642633/
https://www.ncbi.nlm.nih.gov/pubmed/29050358
http://dx.doi.org/10.18632/oncotarget.19333
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author Lukas, Rimas V.
Gondi, Vinai
Kamson, David O.
Kumthekar, Priya
Salgia, Ravi
author_facet Lukas, Rimas V.
Gondi, Vinai
Kamson, David O.
Kumthekar, Priya
Salgia, Ravi
author_sort Lukas, Rimas V.
collection PubMed
description BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments. DESIGN: A comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed. RESULTS: SCLC brain metastases continue to have a poor prognosis. Both unique aspects of SCLC brain metastases as well as features seen more universally across other solid tumor brain metastases are discussed. Systemic therapeutic studies and radiotherapeutic approaches are reviewed. CONCLUSIONS: A clearer understanding of SCLC brain metastases will help lay the framework for studies which will hopefully translate into meaningful therapeutic options for these patients.
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spelling pubmed-56426332017-10-18 State-of-the-art considerations in small cell lung cancer brain metastases Lukas, Rimas V. Gondi, Vinai Kamson, David O. Kumthekar, Priya Salgia, Ravi Oncotarget Review BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments. DESIGN: A comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed. RESULTS: SCLC brain metastases continue to have a poor prognosis. Both unique aspects of SCLC brain metastases as well as features seen more universally across other solid tumor brain metastases are discussed. Systemic therapeutic studies and radiotherapeutic approaches are reviewed. CONCLUSIONS: A clearer understanding of SCLC brain metastases will help lay the framework for studies which will hopefully translate into meaningful therapeutic options for these patients. Impact Journals LLC 2017-07-18 /pmc/articles/PMC5642633/ /pubmed/29050358 http://dx.doi.org/10.18632/oncotarget.19333 Text en Copyright: © 2017 Lukas et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Lukas, Rimas V.
Gondi, Vinai
Kamson, David O.
Kumthekar, Priya
Salgia, Ravi
State-of-the-art considerations in small cell lung cancer brain metastases
title State-of-the-art considerations in small cell lung cancer brain metastases
title_full State-of-the-art considerations in small cell lung cancer brain metastases
title_fullStr State-of-the-art considerations in small cell lung cancer brain metastases
title_full_unstemmed State-of-the-art considerations in small cell lung cancer brain metastases
title_short State-of-the-art considerations in small cell lung cancer brain metastases
title_sort state-of-the-art considerations in small cell lung cancer brain metastases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642633/
https://www.ncbi.nlm.nih.gov/pubmed/29050358
http://dx.doi.org/10.18632/oncotarget.19333
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