Cargando…
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients
INTRODUCTION: Sepsis is a common, costly and morbid cause of critical illness in trauma and surgical patients. Ongoing advances in sepsis resuscitation and critical care support strategies have led to improved in-hospital mortality. However, these patients now survive to enter state of chronic criti...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642775/ https://www.ncbi.nlm.nih.gov/pubmed/28765125 http://dx.doi.org/10.1136/bmjopen-2016-015136 |
_version_ | 1783271425745879040 |
---|---|
author | Loftus, Tyler J Mira, Juan C Ozrazgat-Baslanti, Tezcan Ghita, Gabriella L Wang, Zhongkai Stortz, Julie A Brumback, Babette A Bihorac, Azra Segal, Mark S Anton, Stephen D Leeuwenburgh, Christiaan Mohr, Alicia M Efron, Philip A Moldawer, Lyle L Moore, Frederick A Brakenridge, Scott C |
author_facet | Loftus, Tyler J Mira, Juan C Ozrazgat-Baslanti, Tezcan Ghita, Gabriella L Wang, Zhongkai Stortz, Julie A Brumback, Babette A Bihorac, Azra Segal, Mark S Anton, Stephen D Leeuwenburgh, Christiaan Mohr, Alicia M Efron, Philip A Moldawer, Lyle L Moore, Frederick A Brakenridge, Scott C |
author_sort | Loftus, Tyler J |
collection | PubMed |
description | INTRODUCTION: Sepsis is a common, costly and morbid cause of critical illness in trauma and surgical patients. Ongoing advances in sepsis resuscitation and critical care support strategies have led to improved in-hospital mortality. However, these patients now survive to enter state of chronic critical illness (CCI), persistent low-grade organ dysfunction and poor long-term outcomes driven by the persistent inflammation, immunosuppression and catabolism syndrome (PICS). The Sepsis and Critical Illness Research Center (SCIRC) was created to provide a platform by which the prevalence and pathogenesis of CCI and PICS may be understood at a mechanistic level across multiple medical disciplines, leading to the development of novel management strategies and targeted therapies. METHODS: Here, we describe the design, study cohort and standard operating procedures used in the prospective study of human sepsis at a level 1 trauma centre and tertiary care hospital providing care for over 2600 critically ill patients annually. These procedures include implementation of an automated sepsis surveillance initiative, augmentation of clinical decisions with a computerised sepsis protocol, strategies for direct exportation of quality-filtered data from the electronic medical record to a research database and robust long-term follow-up. ETHICS AND DISSEMINATION: This study has been registered at ClinicalTrials.gov, approved by the University of Florida Institutional Review Board and is actively enrolling subjects. Dissemination of results is forthcoming. |
format | Online Article Text |
id | pubmed-5642775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-56427752017-10-25 Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients Loftus, Tyler J Mira, Juan C Ozrazgat-Baslanti, Tezcan Ghita, Gabriella L Wang, Zhongkai Stortz, Julie A Brumback, Babette A Bihorac, Azra Segal, Mark S Anton, Stephen D Leeuwenburgh, Christiaan Mohr, Alicia M Efron, Philip A Moldawer, Lyle L Moore, Frederick A Brakenridge, Scott C BMJ Open Intensive Care INTRODUCTION: Sepsis is a common, costly and morbid cause of critical illness in trauma and surgical patients. Ongoing advances in sepsis resuscitation and critical care support strategies have led to improved in-hospital mortality. However, these patients now survive to enter state of chronic critical illness (CCI), persistent low-grade organ dysfunction and poor long-term outcomes driven by the persistent inflammation, immunosuppression and catabolism syndrome (PICS). The Sepsis and Critical Illness Research Center (SCIRC) was created to provide a platform by which the prevalence and pathogenesis of CCI and PICS may be understood at a mechanistic level across multiple medical disciplines, leading to the development of novel management strategies and targeted therapies. METHODS: Here, we describe the design, study cohort and standard operating procedures used in the prospective study of human sepsis at a level 1 trauma centre and tertiary care hospital providing care for over 2600 critically ill patients annually. These procedures include implementation of an automated sepsis surveillance initiative, augmentation of clinical decisions with a computerised sepsis protocol, strategies for direct exportation of quality-filtered data from the electronic medical record to a research database and robust long-term follow-up. ETHICS AND DISSEMINATION: This study has been registered at ClinicalTrials.gov, approved by the University of Florida Institutional Review Board and is actively enrolling subjects. Dissemination of results is forthcoming. BMJ Publishing Group 2017-08-01 /pmc/articles/PMC5642775/ /pubmed/28765125 http://dx.doi.org/10.1136/bmjopen-2016-015136 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Intensive Care Loftus, Tyler J Mira, Juan C Ozrazgat-Baslanti, Tezcan Ghita, Gabriella L Wang, Zhongkai Stortz, Julie A Brumback, Babette A Bihorac, Azra Segal, Mark S Anton, Stephen D Leeuwenburgh, Christiaan Mohr, Alicia M Efron, Philip A Moldawer, Lyle L Moore, Frederick A Brakenridge, Scott C Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients |
title | Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients |
title_full | Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients |
title_fullStr | Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients |
title_full_unstemmed | Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients |
title_short | Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients |
title_sort | sepsis and critical illness research center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients |
topic | Intensive Care |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642775/ https://www.ncbi.nlm.nih.gov/pubmed/28765125 http://dx.doi.org/10.1136/bmjopen-2016-015136 |
work_keys_str_mv | AT loftustylerj sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT mirajuanc sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT ozrazgatbaslantitezcan sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT ghitagabriellal sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT wangzhongkai sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT stortzjuliea sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT brumbackbabettea sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT bihoracazra sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT segalmarks sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT antonstephend sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT leeuwenburghchristiaan sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT mohraliciam sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT efronphilipa sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT moldawerlylel sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT moorefredericka sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients AT brakenridgescottc sepsisandcriticalillnessresearchcenterinvestigatorsprotocolsandstandardoperatingproceduresforaprospectivecohortstudyofsepsisincriticallyillsurgicalpatients |