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Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos
The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed during gametogenesis and preimplantation development. It was previously shown that oocyte-derived DNMT1 (a maintenance methyltransferase) is essential for maintaining and propagating CG methylation at imprint...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643148/ https://www.ncbi.nlm.nih.gov/pubmed/28976982 http://dx.doi.org/10.1371/journal.pgen.1007042 |