NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and matur...

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Detalles Bibliográficos
Autores principales: Wang, Jianrong, He, Nanhai, Zhang, Na, Quan, Dexian, Zhang, Shuo, Zhang, Caroline, Yu, Ruth T., Atkins, Annette R., Zhu, Ruihong, Yang, Chunhui, Cui, Ying, Liddle, Christopher, Downes, Michael, Xiao, Hui, Zheng, Ye, Auwerx, Johan, Evans, Ronald M., Leng, Qibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643384/
https://www.ncbi.nlm.nih.gov/pubmed/29038463
http://dx.doi.org/10.1038/s41467-017-00931-8

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