Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships

Few opioid ligands binding to the three classic opioid receptor subtypes, mu, kappa and delta, have high affinity at the fourth opioid receptor, the nociceptin/orphanin FQ receptor (NOP). We recently reported the discovery of AT-076 (1), (R)-7-hydroxy-N-((S)-1-(4-(3-hydroxyphenyl)piperidin-1-yl)-3-m...

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Detalles Bibliográficos
Autores principales: Journigan, V. Blair, Polgar, Willma E., Tuan, Edward W., Lu, James, Daga, Pankaj R., Zaveri, Nurulain T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643385/
https://www.ncbi.nlm.nih.gov/pubmed/29038479
http://dx.doi.org/10.1038/s41598-017-13129-1

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