Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis

Although recent evidence indicates that gp130 cytokines, Oncostatin M (OSM) and IL-6 are involved in alternative programming of macrophages, their role in lung fibrogenesis is poorly understood. Here, we investigated the effect of transient adenoviral overexpression of OSM or IL-6 in mice during ble...

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Detalles Bibliográficos
Autores principales: Ayaub, Ehab A., Dubey, Anisha, Imani, Jewel, Botelho, Fernando, Kolb, Martin R. J., Richards, Carl D., Ask, Kjetil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643520/
https://www.ncbi.nlm.nih.gov/pubmed/29038604
http://dx.doi.org/10.1038/s41598-017-13511-z

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