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A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies

α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of kno...

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Detalles Bibliográficos
Autores principales:	Luthra, Tania, Agarwal, Rahul, Estari, Mamidala, Adepally, Uma, Sen, Subhabrata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643545/ https://www.ncbi.nlm.nih.gov/pubmed/29038580 http://dx.doi.org/10.1038/s41598-017-13798-y

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