Cargando…

A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents

BACKGROUND: Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities. RESULTS: 4-Methyl-2-phenylthiazole-5-carbohydrazide (2) was used as a synthon to prepare 2-(4-me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gomha, Sobhi M., Abdelaziz, Mohamad R., Kheder, Nabila A., Abdel-aziz, Hassan M., Alterary, Seham, Mabkhot, Yahia N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643583/ https://www.ncbi.nlm.nih.gov/pubmed/29086869 http://dx.doi.org/10.1186/s13065-017-0335-8

Ejemplares similares

A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety
por: Gomha, Sobhi M., et al.
Publicado: (2017)

Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety
por: Kheder, Nabila Abdelshafy, et al.
Publicado: (2012)

One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
por: Gomha, Sobhi M., et al.
Publicado: (2016)

Synthesis and Biological Evaluation of Some Novel Thiazole-Based Heterocycles as Potential Anticancer and Antimicrobial Agents
por: Abu-Melha, Sraa, et al.
Publicado: (2019)

Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents
por: Gomha, Sobhi M., et al.
Publicado: (2016)

Eco-Friendly Synthesis, Characterization and Biological Evaluation of Some Novel Pyrazolines Containing Thiazole Moiety as Potential Anticancer and Antimicrobial Agents
por: Edrees, Mastoura M., et al.
Publicado: (2018)

Synthesis and Anticancer Evaluation of New Thiazole and Thiadiazole Derivatives Bearing Acetanilide Moiety
por: El-Rayyes, Ali, et al.
Publicado: (2022)

Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety
por: Abouzied, Amr S., et al.
Publicado: (2022)

Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole Moiety
por: Gomha, Sobhi M., et al.
Publicado: (2015)

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety
por: Abdelriheem, Nadia A., et al.
Publicado: (2017)

Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents
por: Mabkhot, Yahia N., et al.
Publicado: (2018)

Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
por: Alsayari, Abdulrhman, et al.
Publicado: (2021)

Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates
por: Rashdan, Huda R. M., et al.
Publicado: (2020)

A Novel and Expedient Approach to New Thiazoles, Thiazolo[3,2-a]pyridines, Dihydrothiophenes, and Hydrazones Incorporating Thieno[2,3-b]thiophene Moiety
por: Mabkhot, Yahia Nasser, et al.
Publicado: (2012)

Potential COVID-19 Drug Candidates Based on Diazinyl-Thiazol-Imine Moieties: Synthesis and Greener Pastures Biological Study
por: Abu-Melha, Sraa, et al.
Publicado: (2022)

Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M(pro))
por: Abu-Melha, Sraa, et al.
Publicado: (2020)

Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation
por: Gomha, Sobhi M., et al.
Publicado: (2011)

Novel thiazole derivatives incorporating phenyl sulphonyl moiety as potent BRAFV600E kinase inhibitors targeting melanoma
por: Khormi, Afaf Y., et al.
Publicado: (2022)

Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents
por: El-Naggar, Mohamed, et al.
Publicado: (2019)

Synthesis, Antitumor Evaluation and Molecular Docking of New Morpholine Based Heterocycles
por: Muhammad, Zeinab A., et al.
Publicado: (2017)

Efficient, Recyclable, and Heterogeneous Base Nanocatalyst for Thiazoles with a Chitosan-Capped Calcium Oxide Nanocomposite
por: Khalil, Khaled D., et al.
Publicado: (2022)

A Convenient Ultrasound-Promoted Synthesis of Some New Thiazole Derivatives Bearing a Coumarin Nucleus and Their Cytotoxic Activity
por: Gomha, Sobhi M., et al.
Publicado: (2012)

5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
por: Gomha, Sobhi M, et al.
Publicado: (2018)

Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents
por: Gomha, Sobhi M., et al.
Publicado: (2017)

Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug
por: Gomha, Sobhi M., et al.
Publicado: (2015)

A synergistic investigation of azo-thiazole derivatives incorporating thiazole moieties: a comprehensive exploration of their synthesis, characterization, computational insights, solvatochromism, and multimodal biological activity assessment
por: Muhammed Aziz, Dara, et al.
Publicado: (2023)

Chitosan-MgO Nanocomposite: One Pot Preparation and Its Utility as an Ecofriendly Biocatalyst in the Synthesis of Thiazoles and [1,3,4]thiadiazoles
por: Riyadh, Sayed M., et al.
Publicado: (2018)

Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents
por: Khidre, Rizk E., et al.
Publicado: (2021)

One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents
por: Sayed, Abdelwahed R, et al.
Publicado: (2020)

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study
por: Gomha, Sobhi M, et al.
Publicado: (2021)

Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety
por: Sayed, Mariam T., et al.
Publicado: (2023)

Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds
por: Gomha, Sobhi M., et al.
Publicado: (2022)

Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity
por: Abdelhamid, Abdou O., et al.
Publicado: (2015)

Evaluation of the Binding Relationship of the RdRp Enzyme to Novel Thiazole/Acid Hydrazone Hybrids Obtainable through Green Synthetic Procedure
por: Al-Humaidi, Jehan Y., et al.
Publicado: (2022)

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2018)

Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety
por: Shu, Yafei, et al.
Publicado: (2022)

New 1,3,4-Thiadiazole Derivatives with Anticancer Activity
por: Janowska, Sara, et al.
Publicado: (2022)

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents
por: Arshad, Mohammed F., et al.
Publicado: (2022)

Molecular iodine-promoted oxidative cyclization for the synthesis of 1,3,4-thiadiazole-fused- [1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety as potent inhibitors of α-amylase and α-glucosidase: In vitro and in silico study
por: Hussain, Rafaqat, et al.
Publicado: (2022)

Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles
por: Desai, N.C., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tk6hp83bv25hlkgo1289ov7ddk