High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review

BACKGROUND: Recent observational studies have suggested that the patients with hyperuricemia have a higher risk of having left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE), while the ultimate predictive value of a high uric acid (U...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, En-Yuan, Kou, Lu, Li, Min, Ng, Chee Yuan, Zhao, Jian-Ping, Li, Guang-Ping, Liu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2016
Materias:
Meta Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643743/
https://www.ncbi.nlm.nih.gov/pubmed/29063022
http://dx.doi.org/10.1016/j.cdtm.2016.02.002
Descripción
Sumario:BACKGROUND: Recent observational studies have suggested that the patients with hyperuricemia have a higher risk of having left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE), while the ultimate predictive value of a high uric acid (UA) level on LATH/LASEC remained obscure. METHODS: We searched the PubMed and Cochrane clinical trials databases up to July 2015. Following screening the 369 initially identified studies, we analyzed six observational studies with 2381 patients. RESULTS: The meta-analysis of these studies showed that an elevated serum UA level was associated with a higher likelihood of LATH/LASEC (OR = 1.59, 95%CI 1.13–2.23, P = 0.008), while significant differences exist among individual trials (P < 0.00001 and I(2) = 85%). Sensitivity analysis failed to find any heterogeneity. CONCLUSION: An elevated UA level was associated with a higher risk of detecting a left atrial abnormality represented by LATH/LASEC.

Ejemplares similares