KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRN...

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Autores principales: Yu, Shuang-Ni, Ma, Yi-Hui, Zhao, Wu-Gan, Jin, Xiang-Lan, Yang, Hai-Yan, Liu, Ping-Ping, Chen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2016
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643763/
https://www.ncbi.nlm.nih.gov/pubmed/29063045
http://dx.doi.org/10.1016/j.cdtm.2016.11.012
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author Yu, Shuang-Ni
Ma, Yi-Hui
Zhao, Wu-Gan
Jin, Xiang-Lan
Yang, Hai-Yan
Liu, Ping-Ping
Chen, Jie
author_facet Yu, Shuang-Ni
Ma, Yi-Hui
Zhao, Wu-Gan
Jin, Xiang-Lan
Yang, Hai-Yan
Liu, Ping-Ping
Chen, Jie
author_sort Yu, Shuang-Ni
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.
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spelling pubmed-56437632017-10-23 KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma Yu, Shuang-Ni Ma, Yi-Hui Zhao, Wu-Gan Jin, Xiang-Lan Yang, Hai-Yan Liu, Ping-Ping Chen, Jie Chronic Dis Transl Med Perspective Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC. KeAi Publishing 2016-12-22 /pmc/articles/PMC5643763/ /pubmed/29063045 http://dx.doi.org/10.1016/j.cdtm.2016.11.012 Text en © 2016 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Perspective
Yu, Shuang-Ni
Ma, Yi-Hui
Zhao, Wu-Gan
Jin, Xiang-Lan
Yang, Hai-Yan
Liu, Ping-Ping
Chen, Jie
KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_full KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_fullStr KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_full_unstemmed KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_short KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_sort kras-related noncoding rnas in pancreatic ductal adenocarcinoma
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643763/
https://www.ncbi.nlm.nih.gov/pubmed/29063045
http://dx.doi.org/10.1016/j.cdtm.2016.11.012
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