Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review

Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches...

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Detalles Bibliográficos
Autores principales: Tian, Ming, Yuan, Yun-Chuan, Li, Jia-Yi, Gionfriddo, Michael R., Huang, Rong-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643772/
https://www.ncbi.nlm.nih.gov/pubmed/29062983
http://dx.doi.org/10.1016/j.cdtm.2015.02.002
Descripción
Sumario:Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI.

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