Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review

Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches...

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Detalles Bibliográficos
Autores principales: Tian, Ming, Yuan, Yun-Chuan, Li, Jia-Yi, Gionfriddo, Michael R., Huang, Rong-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643772/
https://www.ncbi.nlm.nih.gov/pubmed/29062983
http://dx.doi.org/10.1016/j.cdtm.2015.02.002
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author Tian, Ming
Yuan, Yun-Chuan
Li, Jia-Yi
Gionfriddo, Michael R.
Huang, Rong-Chong
author_facet Tian, Ming
Yuan, Yun-Chuan
Li, Jia-Yi
Gionfriddo, Michael R.
Huang, Rong-Chong
author_sort Tian, Ming
collection PubMed
description Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI.
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spelling pubmed-56437722017-10-23 Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review Tian, Ming Yuan, Yun-Chuan Li, Jia-Yi Gionfriddo, Michael R. Huang, Rong-Chong Chronic Dis Transl Med Review Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI. KeAi Publishing 2015-03-22 /pmc/articles/PMC5643772/ /pubmed/29062983 http://dx.doi.org/10.1016/j.cdtm.2015.02.002 Text en © 2015 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Tian, Ming
Yuan, Yun-Chuan
Li, Jia-Yi
Gionfriddo, Michael R.
Huang, Rong-Chong
Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review
title Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review
title_full Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review
title_fullStr Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review
title_full_unstemmed Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review
title_short Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review
title_sort tumor necrosis factor-α and its role as a mediator in myocardial infarction: a brief review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643772/
https://www.ncbi.nlm.nih.gov/pubmed/29062983
http://dx.doi.org/10.1016/j.cdtm.2015.02.002
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