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The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis

BACKGROUND: The aim of this systematic review and meta-analysis was to summarize the association of obstructive sleep apnea (OSA) with renal outcome. METHODS: Our study followed the PRISMA guidelines. Two independent reviewers searched for relevant articles in the databases of Pubmed, the Web of Sci...

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Autores principales: Hwu, Der-Wei, Lin, Kun-Der, Lin, Kun-Chen, Lee, Yau-Jiunn, Chang, Yu-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644098/
https://www.ncbi.nlm.nih.gov/pubmed/29037156
http://dx.doi.org/10.1186/s12882-017-0731-2
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author Hwu, Der-Wei
Lin, Kun-Der
Lin, Kun-Chen
Lee, Yau-Jiunn
Chang, Yu-Hung
author_facet Hwu, Der-Wei
Lin, Kun-Der
Lin, Kun-Chen
Lee, Yau-Jiunn
Chang, Yu-Hung
author_sort Hwu, Der-Wei
collection PubMed
description BACKGROUND: The aim of this systematic review and meta-analysis was to summarize the association of obstructive sleep apnea (OSA) with renal outcome. METHODS: Our study followed the PRISMA guidelines. Two independent reviewers searched for relevant articles in the databases of Pubmed, the Web of Science and CENTRAL, and conducted study selection and quality assessment. A random-effect model was used to estimate the effects. RESULTS: A total of 1240 articles were initially identified (Pubmed = 568, Web of Science = 640, CENTRAL = 32). After removal of duplicate articles (n = 415) and irrelevant articles (n = 788), 37 were selected for full-text review, and 18 were finally included in the analysis. Overall, patients diagnosed with OSA were found to have a higher odds ratio (OR) of a poorer renal outcome, with a pooled OR of 1.77 (95% C.I.: 1.37–2.29). The significant association between OSA and a poorer renal outcome was not affected by the medical condition of diabetes mellitus (DM). In addition, we found that OSA was consistently associated with higher albuminuria/proteinuria and a lower estimated glomerular filtration rate (eGFR), with a pooled OR of 1.84 (95% C.I.: 1.24–2.73) and 1.60 (95% C.I.: 1.19–2.16), respectively. A greater OSA severity was also found to be related to a higher OR, with a mild group OR of 1.45 (95% C.I.: 1.19–1.77) and a moderate and severe group OR of 2.39 (95% C.I.: 1.96–2.90). CONCLUSIONS: Our study demonstrated that OSA is significantly associated with poorer renal function.
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spelling pubmed-56440982017-10-18 The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis Hwu, Der-Wei Lin, Kun-Der Lin, Kun-Chen Lee, Yau-Jiunn Chang, Yu-Hung BMC Nephrol Research Article BACKGROUND: The aim of this systematic review and meta-analysis was to summarize the association of obstructive sleep apnea (OSA) with renal outcome. METHODS: Our study followed the PRISMA guidelines. Two independent reviewers searched for relevant articles in the databases of Pubmed, the Web of Science and CENTRAL, and conducted study selection and quality assessment. A random-effect model was used to estimate the effects. RESULTS: A total of 1240 articles were initially identified (Pubmed = 568, Web of Science = 640, CENTRAL = 32). After removal of duplicate articles (n = 415) and irrelevant articles (n = 788), 37 were selected for full-text review, and 18 were finally included in the analysis. Overall, patients diagnosed with OSA were found to have a higher odds ratio (OR) of a poorer renal outcome, with a pooled OR of 1.77 (95% C.I.: 1.37–2.29). The significant association between OSA and a poorer renal outcome was not affected by the medical condition of diabetes mellitus (DM). In addition, we found that OSA was consistently associated with higher albuminuria/proteinuria and a lower estimated glomerular filtration rate (eGFR), with a pooled OR of 1.84 (95% C.I.: 1.24–2.73) and 1.60 (95% C.I.: 1.19–2.16), respectively. A greater OSA severity was also found to be related to a higher OR, with a mild group OR of 1.45 (95% C.I.: 1.19–1.77) and a moderate and severe group OR of 2.39 (95% C.I.: 1.96–2.90). CONCLUSIONS: Our study demonstrated that OSA is significantly associated with poorer renal function. BioMed Central 2017-10-16 /pmc/articles/PMC5644098/ /pubmed/29037156 http://dx.doi.org/10.1186/s12882-017-0731-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Hwu, Der-Wei
Lin, Kun-Der
Lin, Kun-Chen
Lee, Yau-Jiunn
Chang, Yu-Hung
The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
title The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
title_full The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
title_fullStr The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
title_full_unstemmed The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
title_short The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
title_sort association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644098/
https://www.ncbi.nlm.nih.gov/pubmed/29037156
http://dx.doi.org/10.1186/s12882-017-0731-2
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