TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

BACKGROUND: Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer’s Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the multifaceted roles of TREM2 in regulating extracellul...

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Detalles Bibliográficos
Autores principales: Bemiller, Shane M., McCray, Tyler J., Allan, Kevin, Formica, Shane V., Xu, Guixiang, Wilson, Gina, Kokiko-Cochran, Olga N., Crish, Samuel D., Lasagna-Reeves, Cristian A., Ransohoff, Richard M., Landreth, Gary E., Lamb, Bruce T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644120/
https://www.ncbi.nlm.nih.gov/pubmed/29037207
http://dx.doi.org/10.1186/s13024-017-0216-6

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