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YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer

BACKGROUND: Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved in drug resistance and poor prognosis of many neoplastic diseases or cancers. However, investigations identifying new modulators of COX-2 pathway and searching for new chemicals ta...

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Detalles Bibliográficos
Autores principales:	Li, Wei, Cao, Yuanyuan, Xu, Jinling, Wang, Ying, Li, Weijie, Wang, Qian, Hu, Ziwei, Hao, Yaping, Hu, Li, Sun, Yawen, Xu, Guanglin, Ao, Guizhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644195/ https://www.ncbi.nlm.nih.gov/pubmed/29037225 http://dx.doi.org/10.1186/s13046-017-0612-3

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