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Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

BACKGROUND: In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrophages within the brain although the impact of individual ART drugs on viral inf...

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Detalles Bibliográficos
Autores principales:	Asahchop, Eugene L., Meziane, Oussama, Mamik, Manmeet K., Chan, Wing F., Branton, William G., Resch, Lothar, Gill, M. John, Haddad, Elie, Guimond, Jean V., Wainberg, Mark A., Baker, Glen B., Cohen, Eric A., Power, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644262/ https://www.ncbi.nlm.nih.gov/pubmed/29037245 http://dx.doi.org/10.1186/s12977-017-0370-5

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