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A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

INTRODUCTION: We conducted a phase Ib proof of mechanism trial to determine whether bexarotene (Targretin) increases central nervous system (CNS) apolipoprotein E (apoE) levels and alters Aβ metabolism in normal healthy individuals with the APOE ε3/ε3 genotype. METHODS: We used stable isotope labeli...

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Detalles Bibliográficos
Autores principales:	Ghosal, Kaushik, Haag, Michael, Verghese, Philip B., West, Tim, Veenstra, Tim, Braunstein, Joel B., Bateman, Randall J., Holtzman, David M., Landreth, Gary E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644280/ https://www.ncbi.nlm.nih.gov/pubmed/29067298 http://dx.doi.org/10.1016/j.trci.2016.06.001

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