Hypogonadism in thalassemia major patients

Despite recent advances in iron chelation therapy, excess iron deposition in pituitary gonadotropic cells remains one of the major problems in thalassemic patients. Hypogonadism, mostly hypogonadotropic hypogonadism, is usually detected during puberty. Early diagnosis and treatment are crucial for n...

Descripción completa

Detalles Bibliográficos
Autores principales: Srisukh, Sasima, Ongphiphadhanakul, Boonsong, Bunnag, Pongamorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644428/
https://www.ncbi.nlm.nih.gov/pubmed/29067234
http://dx.doi.org/10.1016/j.jcte.2016.08.001
_version_ 1783271730895126528
author Srisukh, Sasima
Ongphiphadhanakul, Boonsong
Bunnag, Pongamorn
author_facet Srisukh, Sasima
Ongphiphadhanakul, Boonsong
Bunnag, Pongamorn
author_sort Srisukh, Sasima
collection PubMed
description Despite recent advances in iron chelation therapy, excess iron deposition in pituitary gonadotropic cells remains one of the major problems in thalassemic patients. Hypogonadism, mostly hypogonadotropic hypogonadism, is usually detected during puberty. Early diagnosis and treatment are crucial for normal pubertal development and to reduce the complications of hypogonadism. The risks and benefits of hormonal replacement therapy, especially regarding the thromboembolic event, remain a challenge for providers caring for thalassemic patients.
format Online
Article
Text
id pubmed-5644428
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-56444282017-10-24 Hypogonadism in thalassemia major patients Srisukh, Sasima Ongphiphadhanakul, Boonsong Bunnag, Pongamorn J Clin Transl Endocrinol Review Despite recent advances in iron chelation therapy, excess iron deposition in pituitary gonadotropic cells remains one of the major problems in thalassemic patients. Hypogonadism, mostly hypogonadotropic hypogonadism, is usually detected during puberty. Early diagnosis and treatment are crucial for normal pubertal development and to reduce the complications of hypogonadism. The risks and benefits of hormonal replacement therapy, especially regarding the thromboembolic event, remain a challenge for providers caring for thalassemic patients. Elsevier 2016-08-16 /pmc/articles/PMC5644428/ /pubmed/29067234 http://dx.doi.org/10.1016/j.jcte.2016.08.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Srisukh, Sasima
Ongphiphadhanakul, Boonsong
Bunnag, Pongamorn
Hypogonadism in thalassemia major patients
title Hypogonadism in thalassemia major patients
title_full Hypogonadism in thalassemia major patients
title_fullStr Hypogonadism in thalassemia major patients
title_full_unstemmed Hypogonadism in thalassemia major patients
title_short Hypogonadism in thalassemia major patients
title_sort hypogonadism in thalassemia major patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644428/
https://www.ncbi.nlm.nih.gov/pubmed/29067234
http://dx.doi.org/10.1016/j.jcte.2016.08.001
work_keys_str_mv AT srisukhsasima hypogonadisminthalassemiamajorpatients
AT ongphiphadhanakulboonsong hypogonadisminthalassemiamajorpatients
AT bunnagpongamorn hypogonadisminthalassemiamajorpatients

Ejemplares similares