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Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes

AIM: To investigate the effect of a macro-nutrient preload (Inzone Vitality) on blood glucose levels and pregnancy outcomes of gestational diabetes. The preload method involves the ingestion of a smaller amount of a macronutrient composition half an hour before regular meals. The hypothesis was that...

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Autores principales: Li, Li, Xu, Jing, Zhu, Wenyi, Fan, Rong, Bai, Qian, Huang, Chen, Liu, Jun, Li, Zhen, Sederholm, Magnus, Norstedt, Gunnar, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644440/
https://www.ncbi.nlm.nih.gov/pubmed/29067233
http://dx.doi.org/10.1016/j.jcte.2016.04.001
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author Li, Li
Xu, Jing
Zhu, Wenyi
Fan, Rong
Bai, Qian
Huang, Chen
Liu, Jun
Li, Zhen
Sederholm, Magnus
Norstedt, Gunnar
Wang, Jian
author_facet Li, Li
Xu, Jing
Zhu, Wenyi
Fan, Rong
Bai, Qian
Huang, Chen
Liu, Jun
Li, Zhen
Sederholm, Magnus
Norstedt, Gunnar
Wang, Jian
author_sort Li, Li
collection PubMed
description AIM: To investigate the effect of a macro-nutrient preload (Inzone Vitality) on blood glucose levels and pregnancy outcomes of gestational diabetes. The preload method involves the ingestion of a smaller amount of a macronutrient composition half an hour before regular meals. The hypothesis was that preload treatment will reduce postprandial glycemia in gestational diabetes. METHODS: Sixty-six diagnosed cases of gestational diabetes were randomly selected from gynecology and obstetrics outpatient clinic at Xinqiao Hospital in Chongqing. The patients were divided into an intervention group (33 cases) and a control group (33 cases), according to odd–even numbers of the random cases. The intervention group was treated with a macro-nutrient preload given 0.5 h before regular meals and the control group was given a comparative treatment consisting of a milk powder with similar energy content. The two groups were studied until delivery and the measured parameters included fasting blood glucose (FBG), 2-hour postprandial blood glucose (2h-PBG), delivery mode and neonatal birth weight. RESULTS: The two groups showed no differences in FBG or 2h-PBG before the nutritional intervention. FBG and 2h-PBG after intervention and before delivery were significantly lower in the intervention group, treated with the macro nutrient preload compared to the control group (P < 0.01). Changes in FBG and 2h-PBG before and after the intervention were investigated and the difference in the intervention group was significantly greater than corresponding values in the control group (P < 0.05, P < 0.01). The neonatal birth weight and delivery mode was not significantly different (P > 0.05). CONCLUSION: A macro-nutrient composition, used as a preload, is effective in controlling FBG and PBG of gestational diabetes.
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spelling pubmed-56444402017-10-24 Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes Li, Li Xu, Jing Zhu, Wenyi Fan, Rong Bai, Qian Huang, Chen Liu, Jun Li, Zhen Sederholm, Magnus Norstedt, Gunnar Wang, Jian J Clin Transl Endocrinol Research Paper AIM: To investigate the effect of a macro-nutrient preload (Inzone Vitality) on blood glucose levels and pregnancy outcomes of gestational diabetes. The preload method involves the ingestion of a smaller amount of a macronutrient composition half an hour before regular meals. The hypothesis was that preload treatment will reduce postprandial glycemia in gestational diabetes. METHODS: Sixty-six diagnosed cases of gestational diabetes were randomly selected from gynecology and obstetrics outpatient clinic at Xinqiao Hospital in Chongqing. The patients were divided into an intervention group (33 cases) and a control group (33 cases), according to odd–even numbers of the random cases. The intervention group was treated with a macro-nutrient preload given 0.5 h before regular meals and the control group was given a comparative treatment consisting of a milk powder with similar energy content. The two groups were studied until delivery and the measured parameters included fasting blood glucose (FBG), 2-hour postprandial blood glucose (2h-PBG), delivery mode and neonatal birth weight. RESULTS: The two groups showed no differences in FBG or 2h-PBG before the nutritional intervention. FBG and 2h-PBG after intervention and before delivery were significantly lower in the intervention group, treated with the macro nutrient preload compared to the control group (P < 0.01). Changes in FBG and 2h-PBG before and after the intervention were investigated and the difference in the intervention group was significantly greater than corresponding values in the control group (P < 0.05, P < 0.01). The neonatal birth weight and delivery mode was not significantly different (P > 0.05). CONCLUSION: A macro-nutrient composition, used as a preload, is effective in controlling FBG and PBG of gestational diabetes. Elsevier 2016-05-16 /pmc/articles/PMC5644440/ /pubmed/29067233 http://dx.doi.org/10.1016/j.jcte.2016.04.001 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Li, Li
Xu, Jing
Zhu, Wenyi
Fan, Rong
Bai, Qian
Huang, Chen
Liu, Jun
Li, Zhen
Sederholm, Magnus
Norstedt, Gunnar
Wang, Jian
Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
title Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
title_full Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
title_fullStr Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
title_full_unstemmed Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
title_short Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
title_sort effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644440/
https://www.ncbi.nlm.nih.gov/pubmed/29067233
http://dx.doi.org/10.1016/j.jcte.2016.04.001
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