Prolonged febrile illness due to CTX-M-15 extended-spectrum β-lactamase-producing Klebsiella pneumoniae infection in Nigeria

We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led...

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Detalles Bibliográficos
Autores principales: Aboderin, Oladipo A., Adefehinti, Olufemi, Odetoyin, Babatunde W., Olotu, Amadin A., Okeke, Iruka N., Adeodu, Olugbenga O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS OpenJournals 2012
Materias:
Case Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644516/
https://www.ncbi.nlm.nih.gov/pubmed/29062733
http://dx.doi.org/10.4102/ajlm.v1i1.16
Descripción
Sumario:We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.

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