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Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) na...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644532/ https://www.ncbi.nlm.nih.gov/pubmed/29066892 http://dx.doi.org/10.2147/IJN.S139405 |
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author | Yang, Fang Fang, Xueyang Jiang, Wenting Chen, Tianfeng |
author_facet | Yang, Fang Fang, Xueyang Jiang, Wenting Chen, Tianfeng |
author_sort | Yang, Fang |
collection | PubMed |
description | With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) nanosystem was constructed by the polymerization of Ulva lactuca polysaccharide and N-isopropyl acrylamide, decorated with methoxy polyethylene glycol and Arg–Gly–Asp peptide, and encapsulated with anticancer complex [Ru(phen)2p-MOPIP](PF(6))(2)·2H(2)O. The nanosystem was both pH responsive and targeted. Therefore, the cellular uptake of the drug was greatly improved. Moreover, the mUPR@Ru(POP) had strong suppressive effects against vascular endothelial growth factor (VEGF)-induced angiogenesis through apoptosis. The mUPR@Ru(POP) significantly inhibited VEGF-induced human umbilical vein endothelial cell migration, invasion, and tube formation. These findings have presented new insights into the development of antiangiogenesis drugs. |
format | Online Article Text |
id | pubmed-5644532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56445322017-10-24 Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis Yang, Fang Fang, Xueyang Jiang, Wenting Chen, Tianfeng Int J Nanomedicine Original Research With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) nanosystem was constructed by the polymerization of Ulva lactuca polysaccharide and N-isopropyl acrylamide, decorated with methoxy polyethylene glycol and Arg–Gly–Asp peptide, and encapsulated with anticancer complex [Ru(phen)2p-MOPIP](PF(6))(2)·2H(2)O. The nanosystem was both pH responsive and targeted. Therefore, the cellular uptake of the drug was greatly improved. Moreover, the mUPR@Ru(POP) had strong suppressive effects against vascular endothelial growth factor (VEGF)-induced angiogenesis through apoptosis. The mUPR@Ru(POP) significantly inhibited VEGF-induced human umbilical vein endothelial cell migration, invasion, and tube formation. These findings have presented new insights into the development of antiangiogenesis drugs. Dove Medical Press 2017-10-10 /pmc/articles/PMC5644532/ /pubmed/29066892 http://dx.doi.org/10.2147/IJN.S139405 Text en © 2017 Yang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yang, Fang Fang, Xueyang Jiang, Wenting Chen, Tianfeng Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis |
title | Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis |
title_full | Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis |
title_fullStr | Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis |
title_full_unstemmed | Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis |
title_short | Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis |
title_sort | bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644532/ https://www.ncbi.nlm.nih.gov/pubmed/29066892 http://dx.doi.org/10.2147/IJN.S139405 |
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