Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development

Soluble major histocompatibility complex class I polypeptide-related sequence A (sMICA) is a useful marker in surveillance of lung cancer. High serum sMICA level in patients with non-small-cell lung cancer (NSCLC) seems to be a poor prognostic factor being correlated with poor differentiation and ad...

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Autores principales: Cascone, Roberto, Carlucci, Annalisa, Pierdiluca, Matteo, Santini, Mario, Fiorelli, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644548/
https://www.ncbi.nlm.nih.gov/pubmed/29066938
http://dx.doi.org/10.2147/LCTT.S105623
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author Cascone, Roberto
Carlucci, Annalisa
Pierdiluca, Matteo
Santini, Mario
Fiorelli, Alfonso
author_facet Cascone, Roberto
Carlucci, Annalisa
Pierdiluca, Matteo
Santini, Mario
Fiorelli, Alfonso
author_sort Cascone, Roberto
collection PubMed
description Soluble major histocompatibility complex class I polypeptide-related sequence A (sMICA) is a useful marker in surveillance of lung cancer. High serum sMICA level in patients with non-small-cell lung cancer (NSCLC) seems to be a poor prognostic factor being correlated with poor differentiation and advanced stage. However, the low specificity limits its role as a single prognostic marker of NSCLC, but its evaluation, in addition to standard serum markers, could improve the staging of NSCLC. Despite promising, all current studies are insufficient to assess the real efficiency of sMICA as a prognostic marker of NSCLC, and hence, future studies are required to validate it.
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spelling pubmed-56445482017-10-24 Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development Cascone, Roberto Carlucci, Annalisa Pierdiluca, Matteo Santini, Mario Fiorelli, Alfonso Lung Cancer (Auckl) Review Soluble major histocompatibility complex class I polypeptide-related sequence A (sMICA) is a useful marker in surveillance of lung cancer. High serum sMICA level in patients with non-small-cell lung cancer (NSCLC) seems to be a poor prognostic factor being correlated with poor differentiation and advanced stage. However, the low specificity limits its role as a single prognostic marker of NSCLC, but its evaluation, in addition to standard serum markers, could improve the staging of NSCLC. Despite promising, all current studies are insufficient to assess the real efficiency of sMICA as a prognostic marker of NSCLC, and hence, future studies are required to validate it. Dove Medical Press 2017-10-10 /pmc/articles/PMC5644548/ /pubmed/29066938 http://dx.doi.org/10.2147/LCTT.S105623 Text en © 2017 Cascone et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Cascone, Roberto
Carlucci, Annalisa
Pierdiluca, Matteo
Santini, Mario
Fiorelli, Alfonso
Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_full Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_fullStr Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_full_unstemmed Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_short Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_sort prognostic value of soluble major histocompatibility complex class i polypeptide-related sequence a in non-small-cell lung cancer – significance and development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644548/
https://www.ncbi.nlm.nih.gov/pubmed/29066938
http://dx.doi.org/10.2147/LCTT.S105623
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