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An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth

OBJECTIVE: Although the human adenovirus 36 (Ad-36) is associated with obesity and relative hypolipidemia, its role in pediatric weight loss treatment response is uncertain. Therefore, the primary study objective was to determine whether Ad-36 antibody (AB) status was associated with response to a p...

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Autores principales: Vander Wal, Jillon S., Huelsing, Jean, Dubuisson, Olga, Dhurandhar, Nikhil V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger GmbH 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644750/
https://www.ncbi.nlm.nih.gov/pubmed/23751249
http://dx.doi.org/10.1159/000353109
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author Vander Wal, Jillon S.
Huelsing, Jean
Dubuisson, Olga
Dhurandhar, Nikhil V.
author_facet Vander Wal, Jillon S.
Huelsing, Jean
Dubuisson, Olga
Dhurandhar, Nikhil V.
author_sort Vander Wal, Jillon S.
collection PubMed
description OBJECTIVE: Although the human adenovirus 36 (Ad-36) is associated with obesity and relative hypolipidemia, its role in pediatric weight loss treatment response is uncertain. Therefore, the primary study objective was to determine whether Ad-36 antibody (AB) status was associated with response to a pediatric weight loss program. The secondary objective was to assess the association between Ad-36 AB status and baseline lipid values. METHODS: Participants included 73 youth aged 10-17 years in a residential camp-based weight loss program. The study examined differences in baseline lipid values between Ad-36 AB+ and AB− youth as well as differences in response to treatment, including indices of body size and fitness. RESULTS: At baseline, results showed that Ad-36 AB+ youth evidenced significantly lower levels of total cholesterol and triglycerides than Ad-36 AB− youth (all p < 0.05). After 4 weeks of treatment, the Ad-36 AB+ youth showed a smaller reduction in BMI percentile than the Ad-36 AB− youth (p < 0.05), a difference of about 0.48 kg. CONCLUSION: Ad-36 AB status showed a weak association with treatment response, but was associated with a better lipid profile. Ad-36 AB status should be assessed in studies of pediatric obesity treatment and prevention.
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spelling pubmed-56447502017-12-04 An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth Vander Wal, Jillon S. Huelsing, Jean Dubuisson, Olga Dhurandhar, Nikhil V. Obes Facts Original Article OBJECTIVE: Although the human adenovirus 36 (Ad-36) is associated with obesity and relative hypolipidemia, its role in pediatric weight loss treatment response is uncertain. Therefore, the primary study objective was to determine whether Ad-36 antibody (AB) status was associated with response to a pediatric weight loss program. The secondary objective was to assess the association between Ad-36 AB status and baseline lipid values. METHODS: Participants included 73 youth aged 10-17 years in a residential camp-based weight loss program. The study examined differences in baseline lipid values between Ad-36 AB+ and AB− youth as well as differences in response to treatment, including indices of body size and fitness. RESULTS: At baseline, results showed that Ad-36 AB+ youth evidenced significantly lower levels of total cholesterol and triglycerides than Ad-36 AB− youth (all p < 0.05). After 4 weeks of treatment, the Ad-36 AB+ youth showed a smaller reduction in BMI percentile than the Ad-36 AB− youth (p < 0.05), a difference of about 0.48 kg. CONCLUSION: Ad-36 AB status showed a weak association with treatment response, but was associated with a better lipid profile. Ad-36 AB status should be assessed in studies of pediatric obesity treatment and prevention. S. Karger GmbH 2013-06 2013-06-05 /pmc/articles/PMC5644750/ /pubmed/23751249 http://dx.doi.org/10.1159/000353109 Text en Copyright © 2013 by S. Karger GmbH, Freiburg http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Original Article
Vander Wal, Jillon S.
Huelsing, Jean
Dubuisson, Olga
Dhurandhar, Nikhil V.
An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth
title An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth
title_full An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth
title_fullStr An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth
title_full_unstemmed An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth
title_short An Observational Study of the Association between Adenovirus 36 Antibody Status and Weight Loss among Youth
title_sort observational study of the association between adenovirus 36 antibody status and weight loss among youth
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644750/
https://www.ncbi.nlm.nih.gov/pubmed/23751249
http://dx.doi.org/10.1159/000353109
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