Cargando…

Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study

This study examined the heterogeneity in BMI development by identifying distinct developmental trajectories. These trajectories were further investigated by relating them to markers of low-grade inflammation later in life. Data from approximately 400 healthy volunteers participating in the Spokane H...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoekstra, Trynke, Barbosa-Leiker, Celestina, Wright, Bruce R., Twisk, Jos W.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger GmbH 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644842/
https://www.ncbi.nlm.nih.gov/pubmed/24903324
http://dx.doi.org/10.1159/000362570
_version_ 1783271804666642432
author Hoekstra, Trynke
Barbosa-Leiker, Celestina
Wright, Bruce R.
Twisk, Jos W.R.
author_facet Hoekstra, Trynke
Barbosa-Leiker, Celestina
Wright, Bruce R.
Twisk, Jos W.R.
author_sort Hoekstra, Trynke
collection PubMed
description This study examined the heterogeneity in BMI development by identifying distinct developmental trajectories. These trajectories were further investigated by relating them to markers of low-grade inflammation later in life. Data from approximately 400 healthy volunteers participating in the Spokane Heart Study were collected in 2-year intervals, and four waves of data were available for the current analyses. Body weight was measured by BMI and low-grade inflammation by high-sensitivity C-reactive protein (CRP) and fibrinogen. Up to date statistical techniques, i.e. latent class growth models, were used to analyse heterogeneity in body weight, and linear regressions were run to analyse possible associations between trajectories of body weight and CRP/fibrinogen levels. Six trajectories were identified (three stable, two increasing, and one decreasing) which differed significantly on CRP/fibrinogen levels, highlighting the importance of weight trajectories. The differences were only partly explained by variations in lifestyle habits.
format Online
Article
Text
id pubmed-5644842
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher S. Karger GmbH
record_format MEDLINE/PubMed
spelling pubmed-56448422017-12-04 Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study Hoekstra, Trynke Barbosa-Leiker, Celestina Wright, Bruce R. Twisk, Jos W.R. Obes Facts Original Article This study examined the heterogeneity in BMI development by identifying distinct developmental trajectories. These trajectories were further investigated by relating them to markers of low-grade inflammation later in life. Data from approximately 400 healthy volunteers participating in the Spokane Heart Study were collected in 2-year intervals, and four waves of data were available for the current analyses. Body weight was measured by BMI and low-grade inflammation by high-sensitivity C-reactive protein (CRP) and fibrinogen. Up to date statistical techniques, i.e. latent class growth models, were used to analyse heterogeneity in body weight, and linear regressions were run to analyse possible associations between trajectories of body weight and CRP/fibrinogen levels. Six trajectories were identified (three stable, two increasing, and one decreasing) which differed significantly on CRP/fibrinogen levels, highlighting the importance of weight trajectories. The differences were only partly explained by variations in lifestyle habits. S. Karger GmbH 2014-06 2014-06-04 /pmc/articles/PMC5644842/ /pubmed/24903324 http://dx.doi.org/10.1159/000362570 Text en Copyright © 2014 by S. Karger GmbH, Freiburg http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable tothe online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Original Article
Hoekstra, Trynke
Barbosa-Leiker, Celestina
Wright, Bruce R.
Twisk, Jos W.R.
Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
title Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
title_full Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
title_fullStr Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
title_full_unstemmed Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
title_short Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
title_sort effects of long-term developmental patterns of adiposity on levels of c-reactive protein and fibrinogen among north-american men and women: the spokane heart study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644842/
https://www.ncbi.nlm.nih.gov/pubmed/24903324
http://dx.doi.org/10.1159/000362570
work_keys_str_mv AT hoekstratrynke effectsoflongtermdevelopmentalpatternsofadiposityonlevelsofcreactiveproteinandfibrinogenamongnorthamericanmenandwomenthespokaneheartstudy
AT barbosaleikercelestina effectsoflongtermdevelopmentalpatternsofadiposityonlevelsofcreactiveproteinandfibrinogenamongnorthamericanmenandwomenthespokaneheartstudy
AT wrightbrucer effectsoflongtermdevelopmentalpatternsofadiposityonlevelsofcreactiveproteinandfibrinogenamongnorthamericanmenandwomenthespokaneheartstudy
AT twiskjoswr effectsoflongtermdevelopmentalpatternsofadiposityonlevelsofcreactiveproteinandfibrinogenamongnorthamericanmenandwomenthespokaneheartstudy