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A novel LRP1-binding peptide L57 that crosses the blood brain barrier

The blood-brain barrier (BBB) is a major obstacle to drug delivery into the central nervous system (CNS), in particular for macromolecules such as peptides and proteins. However, certain macromolecules can reach the CNS via a receptor-mediated transcytosis (RMT) pathway, and low-density lipoprotein...

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Detalles Bibliográficos
Autores principales: Sakamoto, Kotaro, Shinohara, Tokuyuki, Adachi, Yusuke, Asami, Taiji, Ohtaki, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645116/
https://www.ncbi.nlm.nih.gov/pubmed/29090274
http://dx.doi.org/10.1016/j.bbrep.2017.07.003