Activating Peripheral Innate Immunity Enables Safe and Effective Oncolytic Virotherapy in the Brain

The oncolytic mutant vesicular stomatitis virus VSVΔ51 achieves robust efficacy in multiple extracranial tumor models. Yet for malignancies of the brain, direct intratumoral infusion of VSVΔ51 causes lethal virus-induced neuropathology. Here, we have developed a novel therapeutic regime that uses pe...

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Detalles Bibliográficos
Autores principales: Balathasan, Lukxmi, Tang, Vera A., Yadollahi, Beta, Brun, Jan, Labelle, Melanie, Lefebvre, Charles, Swift, Stephanie L., Stojdl, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645178/
https://www.ncbi.nlm.nih.gov/pubmed/29062886
http://dx.doi.org/10.1016/j.omto.2017.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645178/
https://www.ncbi.nlm.nih.gov/pubmed/29062886
http://dx.doi.org/10.1016/j.omto.2017.09.004

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