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Activating Peripheral Innate Immunity Enables Safe and Effective Oncolytic Virotherapy in the Brain
The oncolytic mutant vesicular stomatitis virus VSVΔ51 achieves robust efficacy in multiple extracranial tumor models. Yet for malignancies of the brain, direct intratumoral infusion of VSVΔ51 causes lethal virus-induced neuropathology. Here, we have developed a novel therapeutic regime that uses pe...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645178/ https://www.ncbi.nlm.nih.gov/pubmed/29062886 http://dx.doi.org/10.1016/j.omto.2017.09.004 |