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The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation

We incorporate three-dimensional (3D) conformation of chromosome (Hi-C) and single-cell RNA sequencing data together with discrete stochastic simulation, to explore the role of chromatin reorganization in determining gene expression heterogeneity during development. While previous research has empha...

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Detalles Bibliográficos
Autores principales:	Golkaram, Mahdi, Jang, Jiwon, Hellander, Stefan, Kosik, Kenneth S., Petzold, Linda R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645312/ https://www.ncbi.nlm.nih.gov/pubmed/29042584 http://dx.doi.org/10.1038/s41598-017-13731-3

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