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Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head

The mechanism behind osteonecrosis of the femoral head (ONFH) remains unclear. The aim of this study was to explore the pathogenesis of ONFH from a biomechanical standpoint to provide a theoretical basis for improved treatments. We compared the bone structure of fractured femoral heads with that of...

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Autores principales: Ma, Jian-xiong, He, Wei-wei, Zhao, Jie, Kuang, Ming-jie, Bai, Hao-hao, Sun, Lei, Lu, Bin, Tian, Ai-xian, Wang, Ying, Dong, Ben-chao, Wang, Yan, Ma, Xin-long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645321/
https://www.ncbi.nlm.nih.gov/pubmed/29042586
http://dx.doi.org/10.1038/s41598-017-13643-2
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author Ma, Jian-xiong
He, Wei-wei
Zhao, Jie
Kuang, Ming-jie
Bai, Hao-hao
Sun, Lei
Lu, Bin
Tian, Ai-xian
Wang, Ying
Dong, Ben-chao
Wang, Yan
Ma, Xin-long
author_facet Ma, Jian-xiong
He, Wei-wei
Zhao, Jie
Kuang, Ming-jie
Bai, Hao-hao
Sun, Lei
Lu, Bin
Tian, Ai-xian
Wang, Ying
Dong, Ben-chao
Wang, Yan
Ma, Xin-long
author_sort Ma, Jian-xiong
collection PubMed
description The mechanism behind osteonecrosis of the femoral head (ONFH) remains unclear. The aim of this study was to explore the pathogenesis of ONFH from a biomechanical standpoint to provide a theoretical basis for improved treatments. We compared the bone structure of fractured femoral heads with that of necrotic femoral heads by Micro-CT scanning and histological evaluation. In addition, we compared the biomechanical properties of each zone in fractured femoral heads with those in necrotic femoral heads by using biomechanical tests. Compared with fractured femoral heads, bone microarchitecture and bone morphometry in necrotic zone and sclerotic zone of necrotic femoral heads have altered markedly. In addition, the biomechanical properties of the necrotic zone in femoral heads weaken markedly, while those of the sclerotic zone strengthen. We hypothesize that discordance between bone structure and function of the femoral head may be involved in the pathogenesis of ONFH and that more attention should be paid to the prevention and treatment of such discordance.
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spelling pubmed-56453212017-10-26 Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head Ma, Jian-xiong He, Wei-wei Zhao, Jie Kuang, Ming-jie Bai, Hao-hao Sun, Lei Lu, Bin Tian, Ai-xian Wang, Ying Dong, Ben-chao Wang, Yan Ma, Xin-long Sci Rep Article The mechanism behind osteonecrosis of the femoral head (ONFH) remains unclear. The aim of this study was to explore the pathogenesis of ONFH from a biomechanical standpoint to provide a theoretical basis for improved treatments. We compared the bone structure of fractured femoral heads with that of necrotic femoral heads by Micro-CT scanning and histological evaluation. In addition, we compared the biomechanical properties of each zone in fractured femoral heads with those in necrotic femoral heads by using biomechanical tests. Compared with fractured femoral heads, bone microarchitecture and bone morphometry in necrotic zone and sclerotic zone of necrotic femoral heads have altered markedly. In addition, the biomechanical properties of the necrotic zone in femoral heads weaken markedly, while those of the sclerotic zone strengthen. We hypothesize that discordance between bone structure and function of the femoral head may be involved in the pathogenesis of ONFH and that more attention should be paid to the prevention and treatment of such discordance. Nature Publishing Group UK 2017-10-17 /pmc/articles/PMC5645321/ /pubmed/29042586 http://dx.doi.org/10.1038/s41598-017-13643-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ma, Jian-xiong
He, Wei-wei
Zhao, Jie
Kuang, Ming-jie
Bai, Hao-hao
Sun, Lei
Lu, Bin
Tian, Ai-xian
Wang, Ying
Dong, Ben-chao
Wang, Yan
Ma, Xin-long
Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head
title Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head
title_full Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head
title_fullStr Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head
title_full_unstemmed Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head
title_short Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head
title_sort bone microarchitecture and biomechanics of the necrotic femoral head
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645321/
https://www.ncbi.nlm.nih.gov/pubmed/29042586
http://dx.doi.org/10.1038/s41598-017-13643-2
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