Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection

Human cytomegalovirus (HCMV) infection is a global concern and highly infectious. HCMV-infected individuals are often carriers with damaged immunity. However few diagnostic indicators block HMCV control and prevention. Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labelin...

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Detalles Bibliográficos
Autores principales: Xie, Ni, Li, Zhonghang, Zuo, Ran, Qi, Suwen, Zhu, Ting, Liu, Litao, Wan, Lili, Yuan, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645357/
https://www.ncbi.nlm.nih.gov/pubmed/29042594
http://dx.doi.org/10.1038/s41598-017-13591-x
Descripción
Sumario:Human cytomegalovirus (HCMV) infection is a global concern and highly infectious. HCMV-infected individuals are often carriers with damaged immunity. However few diagnostic indicators block HMCV control and prevention. Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins.

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