Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection

Human cytomegalovirus (HCMV) infection is a global concern and highly infectious. HCMV-infected individuals are often carriers with damaged immunity. However few diagnostic indicators block HMCV control and prevention. Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labelin...

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Autores principales: Xie, Ni, Li, Zhonghang, Zuo, Ran, Qi, Suwen, Zhu, Ting, Liu, Litao, Wan, Lili, Yuan, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645357/
https://www.ncbi.nlm.nih.gov/pubmed/29042594
http://dx.doi.org/10.1038/s41598-017-13591-x
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author Xie, Ni
Li, Zhonghang
Zuo, Ran
Qi, Suwen
Zhu, Ting
Liu, Litao
Wan, Lili
Yuan, Jianhui
author_facet Xie, Ni
Li, Zhonghang
Zuo, Ran
Qi, Suwen
Zhu, Ting
Liu, Litao
Wan, Lili
Yuan, Jianhui
author_sort Xie, Ni
collection PubMed
description Human cytomegalovirus (HCMV) infection is a global concern and highly infectious. HCMV-infected individuals are often carriers with damaged immunity. However few diagnostic indicators block HMCV control and prevention. Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins.
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spelling pubmed-56453572017-10-26 Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection Xie, Ni Li, Zhonghang Zuo, Ran Qi, Suwen Zhu, Ting Liu, Litao Wan, Lili Yuan, Jianhui Sci Rep Article Human cytomegalovirus (HCMV) infection is a global concern and highly infectious. HCMV-infected individuals are often carriers with damaged immunity. However few diagnostic indicators block HMCV control and prevention. Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins. Nature Publishing Group UK 2017-10-17 /pmc/articles/PMC5645357/ /pubmed/29042594 http://dx.doi.org/10.1038/s41598-017-13591-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Xie, Ni
Li, Zhonghang
Zuo, Ran
Qi, Suwen
Zhu, Ting
Liu, Litao
Wan, Lili
Yuan, Jianhui
Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection
title Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection
title_full Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection
title_fullStr Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection
title_full_unstemmed Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection
title_short Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection
title_sort serum saa1 and apoe are novel indicators for human cytomegalovirus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645357/
https://www.ncbi.nlm.nih.gov/pubmed/29042594
http://dx.doi.org/10.1038/s41598-017-13591-x
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