Targeting WNT Signaling for Multifaceted Glioblastoma Therapy

The WNT signaling pathway has been of great interest to developmental biologists for decades and has more recently become a central topic for study in cancer biology. It is vital for cell growth and regulation of embryogenesis in many organ systems, particularly the CNS and its associated vasculatur...

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Autores principales: McCord, Matthew, Mukouyama, Yoh-suke, Gilbert, Mark R., Jackson, Sadhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645527/
https://www.ncbi.nlm.nih.gov/pubmed/29081735
http://dx.doi.org/10.3389/fncel.2017.00318
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author McCord, Matthew
Mukouyama, Yoh-suke
Gilbert, Mark R.
Jackson, Sadhana
author_facet McCord, Matthew
Mukouyama, Yoh-suke
Gilbert, Mark R.
Jackson, Sadhana
author_sort McCord, Matthew
collection PubMed
description The WNT signaling pathway has been of great interest to developmental biologists for decades and has more recently become a central topic for study in cancer biology. It is vital for cell growth and regulation of embryogenesis in many organ systems, particularly the CNS and its associated vasculature. We summarize the role of WNT in CNS development and describe how WNT signaling makes key contributions to malignant glioma stemness, invasiveness, therapeutic resistance, and angiogenesis. The role of WNT in these mechanisms, along with creation and maintainance of the blood-brain barrier (BBB), points to the potential of WNT as a multi-faceted target in malignant glioma therapy.
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spelling pubmed-56455272017-10-27 Targeting WNT Signaling for Multifaceted Glioblastoma Therapy McCord, Matthew Mukouyama, Yoh-suke Gilbert, Mark R. Jackson, Sadhana Front Cell Neurosci Neuroscience The WNT signaling pathway has been of great interest to developmental biologists for decades and has more recently become a central topic for study in cancer biology. It is vital for cell growth and regulation of embryogenesis in many organ systems, particularly the CNS and its associated vasculature. We summarize the role of WNT in CNS development and describe how WNT signaling makes key contributions to malignant glioma stemness, invasiveness, therapeutic resistance, and angiogenesis. The role of WNT in these mechanisms, along with creation and maintainance of the blood-brain barrier (BBB), points to the potential of WNT as a multi-faceted target in malignant glioma therapy. Frontiers Media S.A. 2017-10-13 /pmc/articles/PMC5645527/ /pubmed/29081735 http://dx.doi.org/10.3389/fncel.2017.00318 Text en Copyright © 2017 McCord, Mukouyama, Gilbert and Jackson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
McCord, Matthew
Mukouyama, Yoh-suke
Gilbert, Mark R.
Jackson, Sadhana
Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
title Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
title_full Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
title_fullStr Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
title_full_unstemmed Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
title_short Targeting WNT Signaling for Multifaceted Glioblastoma Therapy
title_sort targeting wnt signaling for multifaceted glioblastoma therapy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645527/
https://www.ncbi.nlm.nih.gov/pubmed/29081735
http://dx.doi.org/10.3389/fncel.2017.00318
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AT jacksonsadhana targetingwntsignalingformultifacetedglioblastomatherapy

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