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Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response

Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR). This stress response results in expansion of the ER, upregulation of proteins involved in protein folding and degradation, and attenuation...

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Detalles Bibliográficos
Autores principales:	Chalmers, Fiona, van Lith, Marcel, Sweeney, Bernadette, Cain, Katharine, Bulleid, Neil J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645705/ https://www.ncbi.nlm.nih.gov/pubmed/29062910 http://dx.doi.org/10.12688/wellcomeopenres.11764.2

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