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A new bioassay for measuring the strength of IL-6/STAT3 signal inhibition by tocilizumab in patients with rheumatoid arthritis

BACKGROUND: Interleukin-6 (IL-6) transduces signals via phosphorylation of STAT3 (pSTAT3). Tocilizumab (TCZ) is an IL-6 receptor blocker, which, when administered intravenously every 4 weeks, efficiently ameliorates rheumatoid arthritis (RA). Since IL-6 signal strength varies among patients with RA,...

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Detalles Bibliográficos
Autores principales:	Saito, Shuntaro, Suzuki, Katsuya, Yoshimoto, Keiko, Kaneko, Yuko, Matsumoto, Yoshihiro, Yamaoka, Kunihiro, Takeuchi, Tsutomu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645925/ https://www.ncbi.nlm.nih.gov/pubmed/29041951 http://dx.doi.org/10.1186/s13075-017-1434-6

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