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Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws

OBJECTIVE: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. MATERIALS AND METHODS: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjecte...

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Autores principales: Rao, Nian Jing, Wang, Jing Yi, Yu, Ru Qing, Leung, Yiu Yan, Zheng, Li Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646299/
https://www.ncbi.nlm.nih.gov/pubmed/29109954
http://dx.doi.org/10.1155/2017/1560175
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author Rao, Nian Jing
Wang, Jing Yi
Yu, Ru Qing
Leung, Yiu Yan
Zheng, Li Wu
author_facet Rao, Nian Jing
Wang, Jing Yi
Yu, Ru Qing
Leung, Yiu Yan
Zheng, Li Wu
author_sort Rao, Nian Jing
collection PubMed
description OBJECTIVE: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. MATERIALS AND METHODS: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control. All animals were sacrificed four weeks after pulpal exposure, and the mandibles were harvested for radiological and histomorphometrical analysis. RESULTS: Micro computed tomography (μ-CT) examination demonstrated that periapical diseases significantly increased alveolar bone resorption, and the resorption was greatly attenuated by ZA treatment. Concurrent ZA therapy significantly increased bone density and histological osteocyte necrosis in the presence of periapical lesions. CONCLUSION: ZA treatment reduced bone absorption resulting from periapical disease but increased the risk of developing MRONJ in the ovariectomized mouse model.
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spelling pubmed-56462992017-11-06 Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws Rao, Nian Jing Wang, Jing Yi Yu, Ru Qing Leung, Yiu Yan Zheng, Li Wu Biomed Res Int Research Article OBJECTIVE: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. MATERIALS AND METHODS: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control. All animals were sacrificed four weeks after pulpal exposure, and the mandibles were harvested for radiological and histomorphometrical analysis. RESULTS: Micro computed tomography (μ-CT) examination demonstrated that periapical diseases significantly increased alveolar bone resorption, and the resorption was greatly attenuated by ZA treatment. Concurrent ZA therapy significantly increased bone density and histological osteocyte necrosis in the presence of periapical lesions. CONCLUSION: ZA treatment reduced bone absorption resulting from periapical disease but increased the risk of developing MRONJ in the ovariectomized mouse model. Hindawi 2017 2017-10-04 /pmc/articles/PMC5646299/ /pubmed/29109954 http://dx.doi.org/10.1155/2017/1560175 Text en Copyright © 2017 Nian Jing Rao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rao, Nian Jing
Wang, Jing Yi
Yu, Ru Qing
Leung, Yiu Yan
Zheng, Li Wu
Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
title Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
title_full Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
title_fullStr Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
title_full_unstemmed Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
title_short Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
title_sort role of periapical diseases in medication-related osteonecrosis of the jaws
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646299/
https://www.ncbi.nlm.nih.gov/pubmed/29109954
http://dx.doi.org/10.1155/2017/1560175
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