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The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties

Orthopedic implant failure is mainly attributed to the poor bonding of the implant to bone tissue. An effective approach to minimize the implant failure would be modifying the surface of the implant. Strontium (Sr) can stimulate the proliferation and differentiation of osteoblasts and reduce the act...

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Autores principales: Yuan, Ning, Jia, Lili, Geng, Zhen, Wang, Renfeng, Li, Zhaoyang, Yang, Xianjin, Cui, Zhenduo, Zhu, Shengli, Liang, Yanqin, Liu, Yunde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646307/
https://www.ncbi.nlm.nih.gov/pubmed/29109961
http://dx.doi.org/10.1155/2017/9867819
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author Yuan, Ning
Jia, Lili
Geng, Zhen
Wang, Renfeng
Li, Zhaoyang
Yang, Xianjin
Cui, Zhenduo
Zhu, Shengli
Liang, Yanqin
Liu, Yunde
author_facet Yuan, Ning
Jia, Lili
Geng, Zhen
Wang, Renfeng
Li, Zhaoyang
Yang, Xianjin
Cui, Zhenduo
Zhu, Shengli
Liang, Yanqin
Liu, Yunde
author_sort Yuan, Ning
collection PubMed
description Orthopedic implant failure is mainly attributed to the poor bonding of the implant to bone tissue. An effective approach to minimize the implant failure would be modifying the surface of the implant. Strontium (Sr) can stimulate the proliferation and differentiation of osteoblasts and reduce the activity of osteoclasts. In this study, a titanium (Ti) surface was successively functionalized by covalently grafting dopamine, sodium alginate (SA), and Sr(2+) via the electrostatic immobilization method. The as-prepared coatings on the Ti surface were characterized by using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), and contact angle. The results indicated that the Sr-incorporated coatings were successfully prepared and that Sr distributed uniformly on the surface. A long-lasting and sustained Sr release had been observed in Sr(2+) release studies. The Ti/DOPA/SA/Sr exhibited little cytotoxicity and a robust effect of Sr incorporation on the adhesion and spreading of MG63 cells. The proliferation and alkaline phosphatase (ALP) activity of MG63 cells were enhanced by immobilizing Sr(2+) on the SA-grafted Ti. The Sr-containing coatings, which displayed excellent biocompatibility and osteogenic activity, may provide a promising solution for promoting the tissue integration of implants.
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spelling pubmed-56463072017-11-06 The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties Yuan, Ning Jia, Lili Geng, Zhen Wang, Renfeng Li, Zhaoyang Yang, Xianjin Cui, Zhenduo Zhu, Shengli Liang, Yanqin Liu, Yunde Biomed Res Int Research Article Orthopedic implant failure is mainly attributed to the poor bonding of the implant to bone tissue. An effective approach to minimize the implant failure would be modifying the surface of the implant. Strontium (Sr) can stimulate the proliferation and differentiation of osteoblasts and reduce the activity of osteoclasts. In this study, a titanium (Ti) surface was successively functionalized by covalently grafting dopamine, sodium alginate (SA), and Sr(2+) via the electrostatic immobilization method. The as-prepared coatings on the Ti surface were characterized by using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), and contact angle. The results indicated that the Sr-incorporated coatings were successfully prepared and that Sr distributed uniformly on the surface. A long-lasting and sustained Sr release had been observed in Sr(2+) release studies. The Ti/DOPA/SA/Sr exhibited little cytotoxicity and a robust effect of Sr incorporation on the adhesion and spreading of MG63 cells. The proliferation and alkaline phosphatase (ALP) activity of MG63 cells were enhanced by immobilizing Sr(2+) on the SA-grafted Ti. The Sr-containing coatings, which displayed excellent biocompatibility and osteogenic activity, may provide a promising solution for promoting the tissue integration of implants. Hindawi 2017 2017-10-03 /pmc/articles/PMC5646307/ /pubmed/29109961 http://dx.doi.org/10.1155/2017/9867819 Text en Copyright © 2017 Ning Yuan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yuan, Ning
Jia, Lili
Geng, Zhen
Wang, Renfeng
Li, Zhaoyang
Yang, Xianjin
Cui, Zhenduo
Zhu, Shengli
Liang, Yanqin
Liu, Yunde
The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties
title The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties
title_full The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties
title_fullStr The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties
title_full_unstemmed The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties
title_short The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties
title_sort incorporation of strontium in a sodium alginate coating on titanium surfaces for improved biological properties
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646307/
https://www.ncbi.nlm.nih.gov/pubmed/29109961
http://dx.doi.org/10.1155/2017/9867819
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