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Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells
The CRISPR/Cas9 system provides a powerful method for the genetic manipulation of the mammalian genome, allowing knockout of individual genes as well as the generation of genome-wide knockout cell libraries for genetic screening. However, the diploid status of most mammalian cells restricts the appl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646320/ https://www.ncbi.nlm.nih.gov/pubmed/29109740 http://dx.doi.org/10.1155/2017/2601746 |