Cargando…

BDNF at the Synapse: Why Location Matters

Neurotrophic factors, a family of secreted proteins that support the growth, survival and differentiation of neurons, have been intensively studied for decades due to the powerful and diverse effects on neuronal physiology, as well as their therapeutic potential. Such efforts have led to detailed un...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Minseok, Martinowich, Keri, Lee, Francis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646361/
https://www.ncbi.nlm.nih.gov/pubmed/28937692
http://dx.doi.org/10.1038/mp.2017.144
_version_ 1783272067204907008
author Song, Minseok
Martinowich, Keri
Lee, Francis S.
author_facet Song, Minseok
Martinowich, Keri
Lee, Francis S.
author_sort Song, Minseok
collection PubMed
description Neurotrophic factors, a family of secreted proteins that support the growth, survival and differentiation of neurons, have been intensively studied for decades due to the powerful and diverse effects on neuronal physiology, as well as their therapeutic potential. Such efforts have led to detailed understanding on molecular mechanisms of neurotrophic factor signaling. One member, brain-derived neurotrophic factor (BDNF) has drawn much attention due to its pleiotropic role in the central nervous system (CNS) and implications in various brain disorders. In addition, recent advances linking the rapid-acting antidepressant, ketamine to BDNF translation and BDNF-dependent signaling, has re-emphasized the importance of understanding the precise details of BDNF biology at the synapse. While substantial knowledge related to the genetic, epigenetic, cell biological, and biochemical aspects of BDNF biology has now been established, certain aspects related to the precise localization and release of BDNF at the synapse have remained obscure. A recent series of genetic and cell biological studies have shed light on the question -- the site of BDNF release at the synapse. In this Perspectives article, these new insights will be placed in the context of previously unresolved issues related to BDNF biology, as well as how BDNF may function as a downstream mediator of newer pharmacological agents currently under investigation for treating psychiatric disorders.
format Online
Article
Text
id pubmed-5646361
institution National Center for Biotechnology Information
language English
publishDate 2017
record_format MEDLINE/PubMed
spelling pubmed-56463612018-01-25 BDNF at the Synapse: Why Location Matters Song, Minseok Martinowich, Keri Lee, Francis S. Mol Psychiatry Article Neurotrophic factors, a family of secreted proteins that support the growth, survival and differentiation of neurons, have been intensively studied for decades due to the powerful and diverse effects on neuronal physiology, as well as their therapeutic potential. Such efforts have led to detailed understanding on molecular mechanisms of neurotrophic factor signaling. One member, brain-derived neurotrophic factor (BDNF) has drawn much attention due to its pleiotropic role in the central nervous system (CNS) and implications in various brain disorders. In addition, recent advances linking the rapid-acting antidepressant, ketamine to BDNF translation and BDNF-dependent signaling, has re-emphasized the importance of understanding the precise details of BDNF biology at the synapse. While substantial knowledge related to the genetic, epigenetic, cell biological, and biochemical aspects of BDNF biology has now been established, certain aspects related to the precise localization and release of BDNF at the synapse have remained obscure. A recent series of genetic and cell biological studies have shed light on the question -- the site of BDNF release at the synapse. In this Perspectives article, these new insights will be placed in the context of previously unresolved issues related to BDNF biology, as well as how BDNF may function as a downstream mediator of newer pharmacological agents currently under investigation for treating psychiatric disorders. 2017-07-25 2017-10 /pmc/articles/PMC5646361/ /pubmed/28937692 http://dx.doi.org/10.1038/mp.2017.144 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Song, Minseok
Martinowich, Keri
Lee, Francis S.
BDNF at the Synapse: Why Location Matters
title BDNF at the Synapse: Why Location Matters
title_full BDNF at the Synapse: Why Location Matters
title_fullStr BDNF at the Synapse: Why Location Matters
title_full_unstemmed BDNF at the Synapse: Why Location Matters
title_short BDNF at the Synapse: Why Location Matters
title_sort bdnf at the synapse: why location matters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646361/
https://www.ncbi.nlm.nih.gov/pubmed/28937692
http://dx.doi.org/10.1038/mp.2017.144
work_keys_str_mv AT songminseok bdnfatthesynapsewhylocationmatters
AT martinowichkeri bdnfatthesynapsewhylocationmatters
AT leefranciss bdnfatthesynapsewhylocationmatters