Cargando…
BDNF at the Synapse: Why Location Matters
Neurotrophic factors, a family of secreted proteins that support the growth, survival and differentiation of neurons, have been intensively studied for decades due to the powerful and diverse effects on neuronal physiology, as well as their therapeutic potential. Such efforts have led to detailed un...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646361/ https://www.ncbi.nlm.nih.gov/pubmed/28937692 http://dx.doi.org/10.1038/mp.2017.144 |
_version_ | 1783272067204907008 |
---|---|
author | Song, Minseok Martinowich, Keri Lee, Francis S. |
author_facet | Song, Minseok Martinowich, Keri Lee, Francis S. |
author_sort | Song, Minseok |
collection | PubMed |
description | Neurotrophic factors, a family of secreted proteins that support the growth, survival and differentiation of neurons, have been intensively studied for decades due to the powerful and diverse effects on neuronal physiology, as well as their therapeutic potential. Such efforts have led to detailed understanding on molecular mechanisms of neurotrophic factor signaling. One member, brain-derived neurotrophic factor (BDNF) has drawn much attention due to its pleiotropic role in the central nervous system (CNS) and implications in various brain disorders. In addition, recent advances linking the rapid-acting antidepressant, ketamine to BDNF translation and BDNF-dependent signaling, has re-emphasized the importance of understanding the precise details of BDNF biology at the synapse. While substantial knowledge related to the genetic, epigenetic, cell biological, and biochemical aspects of BDNF biology has now been established, certain aspects related to the precise localization and release of BDNF at the synapse have remained obscure. A recent series of genetic and cell biological studies have shed light on the question -- the site of BDNF release at the synapse. In this Perspectives article, these new insights will be placed in the context of previously unresolved issues related to BDNF biology, as well as how BDNF may function as a downstream mediator of newer pharmacological agents currently under investigation for treating psychiatric disorders. |
format | Online Article Text |
id | pubmed-5646361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-56463612018-01-25 BDNF at the Synapse: Why Location Matters Song, Minseok Martinowich, Keri Lee, Francis S. Mol Psychiatry Article Neurotrophic factors, a family of secreted proteins that support the growth, survival and differentiation of neurons, have been intensively studied for decades due to the powerful and diverse effects on neuronal physiology, as well as their therapeutic potential. Such efforts have led to detailed understanding on molecular mechanisms of neurotrophic factor signaling. One member, brain-derived neurotrophic factor (BDNF) has drawn much attention due to its pleiotropic role in the central nervous system (CNS) and implications in various brain disorders. In addition, recent advances linking the rapid-acting antidepressant, ketamine to BDNF translation and BDNF-dependent signaling, has re-emphasized the importance of understanding the precise details of BDNF biology at the synapse. While substantial knowledge related to the genetic, epigenetic, cell biological, and biochemical aspects of BDNF biology has now been established, certain aspects related to the precise localization and release of BDNF at the synapse have remained obscure. A recent series of genetic and cell biological studies have shed light on the question -- the site of BDNF release at the synapse. In this Perspectives article, these new insights will be placed in the context of previously unresolved issues related to BDNF biology, as well as how BDNF may function as a downstream mediator of newer pharmacological agents currently under investigation for treating psychiatric disorders. 2017-07-25 2017-10 /pmc/articles/PMC5646361/ /pubmed/28937692 http://dx.doi.org/10.1038/mp.2017.144 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Song, Minseok Martinowich, Keri Lee, Francis S. BDNF at the Synapse: Why Location Matters |
title | BDNF at the Synapse: Why Location Matters |
title_full | BDNF at the Synapse: Why Location Matters |
title_fullStr | BDNF at the Synapse: Why Location Matters |
title_full_unstemmed | BDNF at the Synapse: Why Location Matters |
title_short | BDNF at the Synapse: Why Location Matters |
title_sort | bdnf at the synapse: why location matters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646361/ https://www.ncbi.nlm.nih.gov/pubmed/28937692 http://dx.doi.org/10.1038/mp.2017.144 |
work_keys_str_mv | AT songminseok bdnfatthesynapsewhylocationmatters AT martinowichkeri bdnfatthesynapsewhylocationmatters AT leefranciss bdnfatthesynapsewhylocationmatters |