Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy

It is widely known that the therapeutic effect of nanoparticle-based chemotherapeutics could be greatly enhanced by the introduction of the photodynamic effect. Herein we report a chlorin e6-incorporated mesoporous silica nanoparticles (MSNs) covered with a polyethylene glycol shell conjugated via a...

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Detalles Bibliográficos
Autores principales: Lee, Junseok, Lee, Yeong Mi, Kim, Jinhwan, Kim, Won Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646714/
https://www.ncbi.nlm.nih.gov/pubmed/29071188
http://dx.doi.org/10.7150/ntno.18576
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author Lee, Junseok
Lee, Yeong Mi
Kim, Jinhwan
Kim, Won Jong
author_facet Lee, Junseok
Lee, Yeong Mi
Kim, Jinhwan
Kim, Won Jong
author_sort Lee, Junseok
collection PubMed
description It is widely known that the therapeutic effect of nanoparticle-based chemotherapeutics could be greatly enhanced by the introduction of the photodynamic effect. Herein we report a chlorin e6-incorporated mesoporous silica nanoparticles (MSNs) covered with a polyethylene glycol shell conjugated via a singlet oxygen-sensitive labile bis(alkylthio)alkene linker (CeAP-L-PEG). In this study, single irradiation with biocompatible red light induced both intracellular doxorubicin release and photochemical internalization, and consequently enhanced anti-cancer effect was observed in vitro and in vivo. This study suggests the potential of our precisely designed nanoparticle system for photodynamically assisted chemotherapy.
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spelling pubmed-56467142017-10-25 Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy Lee, Junseok Lee, Yeong Mi Kim, Jinhwan Kim, Won Jong Nanotheranostics Research Paper It is widely known that the therapeutic effect of nanoparticle-based chemotherapeutics could be greatly enhanced by the introduction of the photodynamic effect. Herein we report a chlorin e6-incorporated mesoporous silica nanoparticles (MSNs) covered with a polyethylene glycol shell conjugated via a singlet oxygen-sensitive labile bis(alkylthio)alkene linker (CeAP-L-PEG). In this study, single irradiation with biocompatible red light induced both intracellular doxorubicin release and photochemical internalization, and consequently enhanced anti-cancer effect was observed in vitro and in vivo. This study suggests the potential of our precisely designed nanoparticle system for photodynamically assisted chemotherapy. Ivyspring International Publisher 2017-05-08 /pmc/articles/PMC5646714/ /pubmed/29071188 http://dx.doi.org/10.7150/ntno.18576 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Lee, Junseok
Lee, Yeong Mi
Kim, Jinhwan
Kim, Won Jong
Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
title Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
title_full Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
title_fullStr Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
title_full_unstemmed Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
title_short Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
title_sort doxorubicin/ce6-loaded nanoparticle coated with polymer via singlet oxygen-sensitive linker for photodynamically assisted chemotherapy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646714/
https://www.ncbi.nlm.nih.gov/pubmed/29071188
http://dx.doi.org/10.7150/ntno.18576
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AT kimjinhwan doxorubicince6loadednanoparticlecoatedwithpolymerviasingletoxygensensitivelinkerforphotodynamicallyassistedchemotherapy
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