No Effect of Levothyroxine and Levothyroxine-Induced Subclinical Thyrotoxicosis on the Pharmacokinetics of Sorafenib in Healthy Male Subjects

Background: Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyrotropin (TSH) suppression. In the Phase 3 DTC trial (DECISION),...

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Detalles Bibliográficos
Autores principales: Huang, Funan, Ajavon, Antoinette, Huang, Erya, Lettieri, John, Liu, Rong, Peña, Carol, Berse, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Original StudiesThyroid Dysfunction: Hypothyroidism, Thyrotoxicosis, and Thyroid Function Tests
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646750/
https://www.ncbi.nlm.nih.gov/pubmed/28741453
http://dx.doi.org/10.1089/thy.2017.0085

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