Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean

Fundamental to biological decision-making is the ability to generate bimodal expression patterns where 2 alternate expression states simultaneously exist. Here, we use a combination of single-cell analysis and mathematical modeling to examine the sources of bimodality in the transcriptional program...

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Detalles Bibliográficos
Autores principales: Razooky, Brandon S., Cao, Youfang, Hansen, Maike M. K., Perelson, Alan S., Simpson, Michael L., Weinberger, Leor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646755/
https://www.ncbi.nlm.nih.gov/pubmed/29045398
http://dx.doi.org/10.1371/journal.pbio.2000841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646755/
https://www.ncbi.nlm.nih.gov/pubmed/29045398
http://dx.doi.org/10.1371/journal.pbio.2000841

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