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Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean
Fundamental to biological decision-making is the ability to generate bimodal expression patterns where 2 alternate expression states simultaneously exist. Here, we use a combination of single-cell analysis and mathematical modeling to examine the sources of bimodality in the transcriptional program...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646755/ https://www.ncbi.nlm.nih.gov/pubmed/29045398 http://dx.doi.org/10.1371/journal.pbio.2000841 |