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Scaffold dependent histone deacetylase (HDAC) inhibitor induced re-equilibration of the subcellular localization and post-translational modification state of class I HDACs

The mechanism of action of histone deacetylase inhibitors (HDACi) is mainly attributed to the inhibition of the deacetylase catalytic activity for their histone substrates. In this study, we analyzed the abundance of class I HDACs in the cytosolic, nuclear soluble and chromatin bound cellular fracti...

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Detalles Bibliográficos
Autores principales:	Hanigan, Thomas W., Taha, Taha Y., Aboukhatwa, Shaimaa M., Frasor, Jonna, Petukhov, Pavel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646865/ https://www.ncbi.nlm.nih.gov/pubmed/29045501 http://dx.doi.org/10.1371/journal.pone.0186620

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