Cargando…

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion but whose molecular function remains obscure. Here, we identify physical and functional interactions between SEIPIN and micros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pagac, Martin, Cooper, Daniel E., Qi, Yanfei, Lukmantara, Ivan E., Mak, Hoi Yin, Wu, Zengying, Tian, Yuan, Liu, Zhonghua, Lei, Mona, Du, Ximing, Ferguson, Charles, Kotevski, Damian, Sadowski, Pawel, Chen, Weiqin, Boroda, Salome, Harris, Thurl E., Liu, George, Parton, Robert G., Huang, Xun, Coleman, Rosalind A., Yang, Hongyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647143/ https://www.ncbi.nlm.nih.gov/pubmed/27806294 http://dx.doi.org/10.1016/j.celrep.2016.10.037

Ejemplares similares

Seipin regulates the formation of nuclear lipid droplets from a distance
por: Du, Ximing, et al.
Publicado: (2020)

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
por: Fei, Weihua, et al.
Publicado: (2008)

Retinyl esters form lipid droplets independently of triacylglycerol and seipin
por: Molenaar, Martijn R., et al.
Publicado: (2021)

Seipin negatively regulates sphingolipid production at the ER–LD contact site
por: Su, Wei-Cheng, et al.
Publicado: (2019)

Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity
por: McGrath, Cody, et al.
Publicado: (2022)

Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation
por: Tian, Yuan, et al.
Publicado: (2011)

Glycerol-3-Phosphate Acyltransferase-2 Is Expressed in Spermatic Germ Cells and Incorporates Arachidonic Acid into Triacylglycerols
por: Cattaneo, Elizabeth R., et al.
Publicado: (2012)

Effect of Single and Combined Expression of Lysophosphatidic Acid Acyltransferase, Glycerol-3-Phosphate Acyltransferase, and Diacylglycerol Acyltransferase on Lipid Accumulation and Composition in Neochloris oleoabundans
por: Muñoz, Camilo F., et al.
Publicado: (2019)

Update on glycerol-3-phosphate acyltransferases: the roles in the development of insulin resistance
por: Yu, Jing, et al.
Publicado: (2018)

Berardinelli–Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing
por: Zhou, Hongyi, et al.
Publicado: (2020)

PI(3)P and DFCP1 regulate the biogenesis of lipid droplets
por: Lukmantara, Ivan, et al.
Publicado: (2022)

Seipin—still a mysterious protein?
por: Salo, Veijo T.
Publicado: (2023)

BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism
por: Zhou, Hongyi, et al.
Publicado: (2022)

Transcriptional Regulation of Acyl-CoA:Glycerol-sn-3-Phosphate Acyltransferases
por: Karasawa, Ken, et al.
Publicado: (2019)

Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization
por: Shen, Wen-Jun, et al.
Publicado: (2022)

Hippocampal Glycerol-3-Phosphate Acyltransferases 4 and BDNF in the Progress of Obesity-Induced Depression
por: Huang, Yin-qiong, et al.
Publicado: (2021)

Exploring Seipin: From Biochemistry to Bioinformatics Predictions
por: Craveiro Sarmento, Aquiles Sales, et al.
Publicado: (2018)

Promethin Is a Conserved Seipin Partner Protein
por: Castro, Inês G., et al.
Publicado: (2019)

Seipin is required for converting nascent to mature lipid droplets
por: Wang, Huajin, et al.
Publicado: (2016)

Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity
por: Wendel, Angela A., et al.
Publicado: (2010)

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
por: Payne, Victoria A., et al.
Publicado: (2008)

Thyrotropin and Obesity: Increased Adipose Triglyceride Content Through Glycerol-3-Phosphate Acyltransferase 3
por: Ma, Shizhan, et al.
Publicado: (2015)

Overexpression of Glycerol-3-Phosphate Acyltransferase from Suaeda salsa Improves Salt Tolerance in Arabidopsis
por: Sui, Na, et al.
Publicado: (2017)

Expression of glycerol-3-phosphate acyltransferase increases non-polar lipid accumulation in Nannochloropsis oceanica
por: Südfeld, Christian, et al.
Publicado: (2023)

Microalgal glycerol-3-phosphate acyltransferase role in galactolipids and high-value storage lipid biosynthesis
por: Zou, Song, et al.
Publicado: (2023)

Towards a mechanistic understanding of lipodystrophy and seipin functions
por: Wee, Kenneth, et al.
Publicado: (2014)

Role of Seipin in Human Diseases and Experimental Animal Models
por: Li, Yuying, et al.
Publicado: (2022)

Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1
por: Stapleton, Cliona M., et al.
Publicado: (2011)

The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
por: Henriksen, Bradley S, et al.
Publicado: (2013)

Glycerol-3-phosphate acyltransferase 4 is essential for the normal development of reproductive organs and the embryo in Brassica napus
por: Chen, Xue, et al.
Publicado: (2014)

A Novel Complementation Assay for Quick and Specific Screen of Genes Encoding Glycerol-3-Phosphate Acyltransferases
por: Lei, Jie, et al.
Publicado: (2018)

Glycerol-3-phosphate O-acyltransferase is required for PBAN-induced sex pheromone biosynthesis in Bombyx mori
por: Du, Mengfang, et al.
Publicado: (2015)

Plastid Glycerol-3-phosphate Acyltransferase Enhanced Plant Growth and Prokaryotic Glycerolipid Synthesis in Brassica napus
por: Kang, Huiling, et al.
Publicado: (2020)

Suppression of Adipogenesis by Pathogenic Seipin Mutant Is Associated with Inflammatory Response
por: Qiu, Wenjie, et al.
Publicado: (2013)

Seipin regulates ER–lipid droplet contacts and cargo delivery
por: Salo, Veijo T, et al.
Publicado: (2016)

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain
por: Cao, Zhe, et al.
Publicado: (2019)

Glycerol-3-Phosphate Acyltransferase 3 (OsGPAT3) is required for anther development and male fertility in rice
por: Men, Xiao, et al.
Publicado: (2017)

Genome-Wide Identification, Sequence Variation, and Expression of the Glycerol-3-Phosphate Acyltransferase (GPAT) Gene Family in Gossypium
por: Cui, Yupeng, et al.
Publicado: (2019)

TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine
por: Li, Yang Emma, et al.
Publicado: (2021)

Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility
por: El Zowalaty, A E, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_prvlmvecqveuklovi1gbg77ib0