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Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase‐induced cardiomyopathy: involvement of mitofusin‐2

BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first‐line cancer treatment, induces cardiotoxicity linked with increased production of myocardial ROS, with Nox2 NADPH oxidase‐derived superoxide reported to play a key role. The aim of this study was to identify...

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Detalles Bibliográficos
Autores principales:	McLaughlin, Declan, Zhao, Youyou, O'Neill, Karla M, Edgar, Kevin S, Dunne, Philip D, Kearney, Anna M, Grieve, David J, McDermott, Barbara J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Themed Section: Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647180/ https://www.ncbi.nlm.nih.gov/pubmed/28261787 http://dx.doi.org/10.1111/bph.13773

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