Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging

Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron–platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as...

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Autores principales: Phan, Thi Tuong Vy, Bui, Nhat Quang, Moorthy, Madhappan Santha, Lee, Kang Dae, Oh, Junghwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647319/
https://www.ncbi.nlm.nih.gov/pubmed/29046993
http://dx.doi.org/10.1186/s11671-017-2337-9
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author Phan, Thi Tuong Vy
Bui, Nhat Quang
Moorthy, Madhappan Santha
Lee, Kang Dae
Oh, Junghwan
author_facet Phan, Thi Tuong Vy
Bui, Nhat Quang
Moorthy, Madhappan Santha
Lee, Kang Dae
Oh, Junghwan
author_sort Phan, Thi Tuong Vy
collection PubMed
description Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron–platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as novel agents for combined photothermal therapy (PTT) and PAI. The obtained PPy-coated FePt NPs (FePt@PPy NPs) showed excellent biocompatibility, photothermal stability, and high near-infrared (NIR) absorbance for the combination of PTT and PAI. In vitro investigation experimentally demonstrated the effectiveness of FePt@PPy NPs in killing cancer cells with NIR laser irradiation. Moreover, the phantom test of PAI used in conjunction with FePt@PPy NPs showed a strong photoacoustic signal. Thus, the novel FePt@PPy NPs could be considered as promising multifunctional nanoparticles for further applications of photo-based diagnosis and treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s11671-017-2337-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-56473192017-10-31 Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging Phan, Thi Tuong Vy Bui, Nhat Quang Moorthy, Madhappan Santha Lee, Kang Dae Oh, Junghwan Nanoscale Res Lett Nano Express Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron–platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as novel agents for combined photothermal therapy (PTT) and PAI. The obtained PPy-coated FePt NPs (FePt@PPy NPs) showed excellent biocompatibility, photothermal stability, and high near-infrared (NIR) absorbance for the combination of PTT and PAI. In vitro investigation experimentally demonstrated the effectiveness of FePt@PPy NPs in killing cancer cells with NIR laser irradiation. Moreover, the phantom test of PAI used in conjunction with FePt@PPy NPs showed a strong photoacoustic signal. Thus, the novel FePt@PPy NPs could be considered as promising multifunctional nanoparticles for further applications of photo-based diagnosis and treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s11671-017-2337-9) contains supplementary material, which is available to authorized users. Springer US 2017-10-18 /pmc/articles/PMC5647319/ /pubmed/29046993 http://dx.doi.org/10.1186/s11671-017-2337-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Phan, Thi Tuong Vy
Bui, Nhat Quang
Moorthy, Madhappan Santha
Lee, Kang Dae
Oh, Junghwan
Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging
title Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging
title_full Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging
title_fullStr Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging
title_full_unstemmed Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging
title_short Synthesis and In Vitro Performance of Polypyrrole-Coated Iron–Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging
title_sort synthesis and in vitro performance of polypyrrole-coated iron–platinum nanoparticles for photothermal therapy and photoacoustic imaging
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647319/
https://www.ncbi.nlm.nih.gov/pubmed/29046993
http://dx.doi.org/10.1186/s11671-017-2337-9
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