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Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2

PURPOSE: To validate the 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and investigate whether a modified classification better reflects...

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Autores principales: Lee, Sumin, Lee, Sang-wook, Park, Sunmin, Yoon, Sang Min, Park, Jin-hong, Song, Si Yeol, Ahn, Seung Do, Kim, Jong Hoon, Choi, Eun Kyung, Kim, Su Ssan, Jung, Jinhong, Kim, Young Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647761/
https://www.ncbi.nlm.nih.gov/pubmed/29037027
http://dx.doi.org/10.3857/roj.2017.00465
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author Lee, Sumin
Lee, Sang-wook
Park, Sunmin
Yoon, Sang Min
Park, Jin-hong
Song, Si Yeol
Ahn, Seung Do
Kim, Jong Hoon
Choi, Eun Kyung
Kim, Su Ssan
Jung, Jinhong
Kim, Young Seok
author_facet Lee, Sumin
Lee, Sang-wook
Park, Sunmin
Yoon, Sang Min
Park, Jin-hong
Song, Si Yeol
Ahn, Seung Do
Kim, Jong Hoon
Choi, Eun Kyung
Kim, Su Ssan
Jung, Jinhong
Kim, Young Seok
author_sort Lee, Sumin
collection PubMed
description PURPOSE: To validate the 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and investigate whether a modified classification better reflects the prognosis. MATERIALS AND METHODS: Medical records of patients diagnosed with non-metastatic HPV-related OPSCC between 2010 and 2016 at a single institution were retrospectively reviewed. HPV status was determined by immunohistochemical analysis of p16 and/or HPV DNA polymerase chain reaction (PCR). We reclassified TNM stage T0-1 and N0-1 as group A, T2-3 or N2 as B, and T4 or N3 as C. Survival analysis according to 8th AJCC/UICC TNM staging and the modified classification was performed. RESULTS: Of 383 OPSCC patients, 211 were positive for HPV DNA PCR or p16. After exclusion, 184 patients were included in this analysis. Median age was 56 years (range, 31 to 81 years). Most primary tumors were in the palatine tonsil (148 tumors, 80%). The eighth AJCC/UICC TNM classification could not differentiate between stage I and II (p = 0.470) or II and III (p = 0.209). Applying modified grouping, the 3-year overall survival rate of group A was significantly higher than that of group B and C (98% vs. 91%, p = 0.039 and 98% vs. 78%, p < 0.001, respectively). Differentiation between group B and C was marginally significant (p = 0.053). CONCLUSION: The 8th AJCC/UICC TNM staging system did not clearly distinguish the prognosis of stage II from that of other stages. Including the T2N0-1 group in stage II may improve prognostic stratification.
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spelling pubmed-56477612017-10-19 Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2 Lee, Sumin Lee, Sang-wook Park, Sunmin Yoon, Sang Min Park, Jin-hong Song, Si Yeol Ahn, Seung Do Kim, Jong Hoon Choi, Eun Kyung Kim, Su Ssan Jung, Jinhong Kim, Young Seok Radiat Oncol J Original Article PURPOSE: To validate the 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and investigate whether a modified classification better reflects the prognosis. MATERIALS AND METHODS: Medical records of patients diagnosed with non-metastatic HPV-related OPSCC between 2010 and 2016 at a single institution were retrospectively reviewed. HPV status was determined by immunohistochemical analysis of p16 and/or HPV DNA polymerase chain reaction (PCR). We reclassified TNM stage T0-1 and N0-1 as group A, T2-3 or N2 as B, and T4 or N3 as C. Survival analysis according to 8th AJCC/UICC TNM staging and the modified classification was performed. RESULTS: Of 383 OPSCC patients, 211 were positive for HPV DNA PCR or p16. After exclusion, 184 patients were included in this analysis. Median age was 56 years (range, 31 to 81 years). Most primary tumors were in the palatine tonsil (148 tumors, 80%). The eighth AJCC/UICC TNM classification could not differentiate between stage I and II (p = 0.470) or II and III (p = 0.209). Applying modified grouping, the 3-year overall survival rate of group A was significantly higher than that of group B and C (98% vs. 91%, p = 0.039 and 98% vs. 78%, p < 0.001, respectively). Differentiation between group B and C was marginally significant (p = 0.053). CONCLUSION: The 8th AJCC/UICC TNM staging system did not clearly distinguish the prognosis of stage II from that of other stages. Including the T2N0-1 group in stage II may improve prognostic stratification. The Korean Society for Radiation Oncology 2017-09 2017-09-29 /pmc/articles/PMC5647761/ /pubmed/29037027 http://dx.doi.org/10.3857/roj.2017.00465 Text en Copyright © 2017. The Korean Society for Radiation Oncology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Sumin
Lee, Sang-wook
Park, Sunmin
Yoon, Sang Min
Park, Jin-hong
Song, Si Yeol
Ahn, Seung Do
Kim, Jong Hoon
Choi, Eun Kyung
Kim, Su Ssan
Jung, Jinhong
Kim, Young Seok
Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2
title Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2
title_full Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2
title_fullStr Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2
title_full_unstemmed Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2
title_short Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2
title_sort refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between t1 and t2
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647761/
https://www.ncbi.nlm.nih.gov/pubmed/29037027
http://dx.doi.org/10.3857/roj.2017.00465
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