Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation

Starvation induces liver autophagy, which is thought to provide nutrients for use by other organs and thereby maintain whole-body homeostasis. Here we demonstrate that O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is required for glucagon-stimulated liver autophagy and metabolic adapta...

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Detalles Bibliográficos
Autores principales: Ruan, Hai-Bin, Ma, Yina, Torres, Sara, Zhang, Bichen, Feriod, Colleen, Heck, Ryan M., Qian, Kevin, Fu, Minnie, Li, Xiuqi, Nathanson, Michael H., Bennett, Anton M., Nie, Yongzhan, Ehrlich, Barbara E., Yang, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647936/
https://www.ncbi.nlm.nih.gov/pubmed/28903979
http://dx.doi.org/10.1101/gad.305441.117

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