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Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 phosphorylation at multiple amino acid residues. W...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647949/ https://www.ncbi.nlm.nih.gov/pubmed/28910579 http://dx.doi.org/10.1080/15592324.2017.1379644 |
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author | Underwood, William Somerville, Shauna C. |
author_facet | Underwood, William Somerville, Shauna C. |
author_sort | Underwood, William |
collection | PubMed |
description | The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 phosphorylation at multiple amino acid residues. Whether PAMP-induced phosphorylation of PEN3 is important for its defense function or focal recruitment has not been addressed. In this study, we evaluated the role of PEN3 phosphorylation in modulating the localization and defense function of the transporter. We report that PEN3 phosphorylation is critical for its function in defense, but dispensable for recruitment to powdery mildew penetration sites. These results indicate that PAMP-induced phosphorylation is likely to regulate the transport activity of PEN3. |
format | Online Article Text |
id | pubmed-5647949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-56479492017-10-27 Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter Underwood, William Somerville, Shauna C. Plant Signal Behav Short Communication The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 phosphorylation at multiple amino acid residues. Whether PAMP-induced phosphorylation of PEN3 is important for its defense function or focal recruitment has not been addressed. In this study, we evaluated the role of PEN3 phosphorylation in modulating the localization and defense function of the transporter. We report that PEN3 phosphorylation is critical for its function in defense, but dispensable for recruitment to powdery mildew penetration sites. These results indicate that PAMP-induced phosphorylation is likely to regulate the transport activity of PEN3. Taylor & Francis 2017-09-14 /pmc/articles/PMC5647949/ /pubmed/28910579 http://dx.doi.org/10.1080/15592324.2017.1379644 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Short Communication Underwood, William Somerville, Shauna C. Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter |
title | Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter |
title_full | Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter |
title_fullStr | Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter |
title_full_unstemmed | Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter |
title_short | Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter |
title_sort | phosphorylation is required for the pathogen defense function of the arabidopsis pen3 abc transporter |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647949/ https://www.ncbi.nlm.nih.gov/pubmed/28910579 http://dx.doi.org/10.1080/15592324.2017.1379644 |
work_keys_str_mv | AT underwoodwilliam phosphorylationisrequiredforthepathogendefensefunctionofthearabidopsispen3abctransporter AT somervilleshaunac phosphorylationisrequiredforthepathogendefensefunctionofthearabidopsispen3abctransporter |